Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

Yung Tai Chen; Chih Chin Yu; Hsin Chih Yeh; Hsiang Ying Lee; Yuan Hong Jiang; Yu Khun Lee; Chia Hao Kuei; Chia Chang Wu; Chao Yuan Huang; Wei Yu Lin; Cheng Kuang Yang; Yao Chou Tsai

doi:10.1038/s41598-021-83495-4

Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

Yung Tai Chen, Chih Chin Yu, Hsin Chih Yeh, Hsiang Ying Lee, Yuan Hong Jiang, Yu Khun Lee, Chia Hao Kuei, Chia Chang Wu, Chao Yuan Huang, Wei Yu Lin, Cheng Kuang Yang, Yao Chou Tsai

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11 Scopus citations

Abstract

Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.

Original language	English (US)
Article number	4040
Journal	Scientific reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-83495-4
State	Published - Dec 2021
Externally published	Yes

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Chen, Y. T., Yu, C. C., Yeh, H. C., Lee, H. Y., Jiang, Y. H., Lee, Y. K., Kuei, C. H., Wu, C. C., Huang, C. Y., Lin, W. Y., Yang, C. K., & Tsai, Y. C. (2021). Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region. Scientific reports, 11(1), Article 4040. https://doi.org/10.1038/s41598-021-83495-4

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title = "Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region",

abstract = "Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.",

author = "Chen, {Yung Tai} and Yu, {Chih Chin} and Yeh, {Hsin Chih} and Lee, {Hsiang Ying} and Jiang, {Yuan Hong} and Lee, {Yu Khun} and Kuei, {Chia Hao} and Wu, {Chia Chang} and Huang, {Chao Yuan} and Lin, {Wei Yu} and Yang, {Cheng Kuang} and Tsai, {Yao Chou}",

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year = "2021",

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doi = "10.1038/s41598-021-83495-4",

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AU - Yu, Chih Chin

AU - Yeh, Hsin Chih

AU - Lee, Hsiang Ying

AU - Jiang, Yuan Hong

AU - Lee, Yu Khun

AU - Kuei, Chia Hao

AU - Wu, Chia Chang

AU - Huang, Chao Yuan

AU - Lin, Wei Yu

AU - Yang, Cheng Kuang

AU - Tsai, Yao Chou

PY - 2021/12

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N2 - Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.

AB - Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.

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Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

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