Endothelial cell studies in patients after photorefractive keratectomy for hyperopia

Nada S. Jabbur, Michael W. Belin, Robert W Bowman, Richard E. Braunstein, Harrison D Cavanagh, David H. Haight, Kenneth Kenyon, Colman Kraff, Manus C. Kraff, James C. Liu, Ezra Maguen, Eric Mandel, Robert J. Masi, James P McCulley, Anthony Nesburn, Terrence P. O'Brien, Yaron Rabinowitz, Peter Rapoza, Robert Schultze, James J. Salz & 11 others Jonathan Talamo, Mark Volpicelli, Robert M. Webb, Marc G. Odrich, Kenneth A. Greenberg, Jerome A. Legerton, David M. Patino, Kitty Legerton, Kris Gambelin, Anais Laborde, Berni DeFrenchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalJournal of Refractive Surgery
Volume19
Issue number2
StatePublished - Mar 2003

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Photorefractive Keratectomy
Hyperopia
Corneal Endothelium
Endothelial Cells
Clinical Trials
Excimer Lasers
Contact Lenses
Cell Size
Multicenter Studies
Microscopy
Software
Cell Count
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Jabbur, N. S., Belin, M. W., Bowman, R. W., Braunstein, R. E., Cavanagh, H. D., Haight, D. H., ... DeFrenchi, B. (2003). Endothelial cell studies in patients after photorefractive keratectomy for hyperopia. Journal of Refractive Surgery, 19(2), 142-148.

Endothelial cell studies in patients after photorefractive keratectomy for hyperopia. / Jabbur, Nada S.; Belin, Michael W.; Bowman, Robert W; Braunstein, Richard E.; Cavanagh, Harrison D; Haight, David H.; Kenyon, Kenneth; Kraff, Colman; Kraff, Manus C.; Liu, James C.; Maguen, Ezra; Mandel, Eric; Masi, Robert J.; McCulley, James P; Nesburn, Anthony; O'Brien, Terrence P.; Rabinowitz, Yaron; Rapoza, Peter; Schultze, Robert; Salz, James J.; Talamo, Jonathan; Volpicelli, Mark; Webb, Robert M.; Odrich, Marc G.; Greenberg, Kenneth A.; Legerton, Jerome A.; Patino, David M.; Legerton, Kitty; Gambelin, Kris; Laborde, Anais; DeFrenchi, Berni.

In: Journal of Refractive Surgery, Vol. 19, No. 2, 03.2003, p. 142-148.

Research output: Contribution to journalArticle

Jabbur, NS, Belin, MW, Bowman, RW, Braunstein, RE, Cavanagh, HD, Haight, DH, Kenyon, K, Kraff, C, Kraff, MC, Liu, JC, Maguen, E, Mandel, E, Masi, RJ, McCulley, JP, Nesburn, A, O'Brien, TP, Rabinowitz, Y, Rapoza, P, Schultze, R, Salz, JJ, Talamo, J, Volpicelli, M, Webb, RM, Odrich, MG, Greenberg, KA, Legerton, JA, Patino, DM, Legerton, K, Gambelin, K, Laborde, A & DeFrenchi, B 2003, 'Endothelial cell studies in patients after photorefractive keratectomy for hyperopia', Journal of Refractive Surgery, vol. 19, no. 2, pp. 142-148.
Jabbur, Nada S. ; Belin, Michael W. ; Bowman, Robert W ; Braunstein, Richard E. ; Cavanagh, Harrison D ; Haight, David H. ; Kenyon, Kenneth ; Kraff, Colman ; Kraff, Manus C. ; Liu, James C. ; Maguen, Ezra ; Mandel, Eric ; Masi, Robert J. ; McCulley, James P ; Nesburn, Anthony ; O'Brien, Terrence P. ; Rabinowitz, Yaron ; Rapoza, Peter ; Schultze, Robert ; Salz, James J. ; Talamo, Jonathan ; Volpicelli, Mark ; Webb, Robert M. ; Odrich, Marc G. ; Greenberg, Kenneth A. ; Legerton, Jerome A. ; Patino, David M. ; Legerton, Kitty ; Gambelin, Kris ; Laborde, Anais ; DeFrenchi, Berni. / Endothelial cell studies in patients after photorefractive keratectomy for hyperopia. In: Journal of Refractive Surgery. 2003 ; Vol. 19, No. 2. pp. 142-148.
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abstract = "PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.",
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AU - Belin, Michael W.

AU - Bowman, Robert W

AU - Braunstein, Richard E.

AU - Cavanagh, Harrison D

AU - Haight, David H.

AU - Kenyon, Kenneth

AU - Kraff, Colman

AU - Kraff, Manus C.

AU - Liu, James C.

AU - Maguen, Ezra

AU - Mandel, Eric

AU - Masi, Robert J.

AU - McCulley, James P

AU - Nesburn, Anthony

AU - O'Brien, Terrence P.

AU - Rabinowitz, Yaron

AU - Rapoza, Peter

AU - Schultze, Robert

AU - Salz, James J.

AU - Talamo, Jonathan

AU - Volpicelli, Mark

AU - Webb, Robert M.

AU - Odrich, Marc G.

AU - Greenberg, Kenneth A.

AU - Legerton, Jerome A.

AU - Patino, David M.

AU - Legerton, Kitty

AU - Gambelin, Kris

AU - Laborde, Anais

AU - DeFrenchi, Berni

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N2 - PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.

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