TY - JOUR
T1 - Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases
AU - Nagai, R.
AU - Saito, Y.
AU - Ohyama, Y.
AU - Aizawa, H.
AU - Suga, T.
AU - Nakamura, T.
AU - Kurabayashi, M.
AU - Kuro-O, M.
PY - 2000
Y1 - 2000
N2 - The human aging process is associated with vascular endothelial dysfunction. However, humoral factors which might protect against endothelial dysfunction during aging have not yet been identified. We recently identified the klotho gene as a possible regulator of human aging. In the present study using the klotho-deficient heterozygous mouse, we examined whether the Klotho protein is a humoral factor protecting against endothelial dysfunction. We further cloned rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress. The Klotho protein itself, or its metabolites, promotes endothelial NO production in aorta as well as arterioles, and klotho mRNA in kidney is downregulated under sustained circulatory stress.
AB - The human aging process is associated with vascular endothelial dysfunction. However, humoral factors which might protect against endothelial dysfunction during aging have not yet been identified. We recently identified the klotho gene as a possible regulator of human aging. In the present study using the klotho-deficient heterozygous mouse, we examined whether the Klotho protein is a humoral factor protecting against endothelial dysfunction. We further cloned rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress. The Klotho protein itself, or its metabolites, promotes endothelial NO production in aorta as well as arterioles, and klotho mRNA in kidney is downregulated under sustained circulatory stress.
KW - Cytokine
KW - Endothelial function
KW - Hypertension
KW - Klotho
KW - Nitric oxide production
KW - Renal failure
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U2 - 10.1007/s000180050038
DO - 10.1007/s000180050038
M3 - Article
C2 - 10892340
AN - SCOPUS:0034130405
SN - 1420-682X
VL - 57
SP - 738
EP - 746
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 5
ER -