Objective: We sought to determine if endothelial microparticles (EMPs), markers of endothelial damage, are associated with soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) in women with preeclampsia. Study Design: A prospective cohort study was conducted on 20 preeclamptic women and 20 controls. EMPs by flow cytometry, sFlt1, soluble endoglin, and PlGF were measured at time of enrollment, 48-hours postpartum, and 1-week postpartum. Results: Preeclamptic CD31+/42-, CD62E+, and CD105+ EMP levels were significantly elevated in preeclamptics vs controls at time of enrollment. The sFlt1:PlGF ratio was correlated with CD31+/42- and CD105+ EMPs (r = 0.69 and r = 0.51, respectively) in preeclampsia. Levels of CD31 +/42- EMPs remained elevated 1-week postpartum (P =.026). Conclusion: EMPs are elevated in preeclampsia. The correlation of EMPs and the sFlt1:PlGF ratio suggests that antiangiogenesis is related to apoptosis of the endothelia. Endothelial damage persists 1 week after delivery.
- endothelial microparticles
- soluble fms-like tyrosine kinase 1:placental growth factor ratio
ASJC Scopus subject areas
- Obstetrics and Gynecology