Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period

Loren Petrozella, Mala Mahendroo, Brenda Timmons, Scott Roberts, Donald McIntire, James M. Alexander

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Objective: We sought to determine if endothelial microparticles (EMPs), markers of endothelial damage, are associated with soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) in women with preeclampsia. Study Design: A prospective cohort study was conducted on 20 preeclamptic women and 20 controls. EMPs by flow cytometry, sFlt1, soluble endoglin, and PlGF were measured at time of enrollment, 48-hours postpartum, and 1-week postpartum. Results: Preeclamptic CD31+/42-, CD62E+, and CD105+ EMP levels were significantly elevated in preeclamptics vs controls at time of enrollment. The sFlt1:PlGF ratio was correlated with CD31+/42- and CD105+ EMPs (r = 0.69 and r = 0.51, respectively) in preeclampsia. Levels of CD31 +/42- EMPs remained elevated 1-week postpartum (P =.026). Conclusion: EMPs are elevated in preeclampsia. The correlation of EMPs and the sFlt1:PlGF ratio suggests that antiangiogenesis is related to apoptosis of the endothelia. Endothelial damage persists 1 week after delivery.

Original languageEnglish (US)
Pages (from-to)140.e20-140.e26
JournalAmerican journal of obstetrics and gynecology
Volume207
Issue number2
DOIs
StatePublished - Aug 2012

Keywords

  • endothelial microparticles
  • preeclampsia
  • pregnancy
  • soluble fms-like tyrosine kinase 1:placental growth factor ratio

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period'. Together they form a unique fingerprint.

  • Cite this