Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period

Loren Petrozella, Mala Mahendroo, Brenda Timmons, Scott Roberts, Donald McIntire, James M. Alexander

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: We sought to determine if endothelial microparticles (EMPs), markers of endothelial damage, are associated with soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) in women with preeclampsia. Study Design: A prospective cohort study was conducted on 20 preeclamptic women and 20 controls. EMPs by flow cytometry, sFlt1, soluble endoglin, and PlGF were measured at time of enrollment, 48-hours postpartum, and 1-week postpartum. Results: Preeclamptic CD31 +/42 -, CD62E +, and CD105 + EMP levels were significantly elevated in preeclamptics vs controls at time of enrollment. The sFlt1:PlGF ratio was correlated with CD31 +/42 - and CD105 + EMPs (r = 0.69 and r = 0.51, respectively) in preeclampsia. Levels of CD31 +/42 - EMPs remained elevated 1-week postpartum (P =.026). Conclusion: EMPs are elevated in preeclampsia. The correlation of EMPs and the sFlt1:PlGF ratio suggests that antiangiogenesis is related to apoptosis of the endothelia. Endothelial damage persists 1 week after delivery.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume207
Issue number2
DOIs
StatePublished - Aug 2012

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Vascular Endothelial Growth Factor Receptor-1
Pre-Eclampsia
Postpartum Period
Intercellular Signaling Peptides and Proteins
Endothelium
Flow Cytometry
Cohort Studies
Prospective Studies
Apoptosis
Endoglin

Keywords

  • endothelial microparticles
  • preeclampsia
  • pregnancy
  • soluble fms-like tyrosine kinase 1:placental growth factor ratio

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period. / Petrozella, Loren; Mahendroo, Mala; Timmons, Brenda; Roberts, Scott; McIntire, Donald; Alexander, James M.

In: American Journal of Obstetrics and Gynecology, Vol. 207, No. 2, 08.2012.

Research output: Contribution to journalArticle

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AU - Alexander, James M.

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