Endothelial response to venous injury

W. Krupski, E. R. Thal, B. L. Gewertz, L. M. Buja, M. E. Murphy, H. K. Hagler, W. J. Fry

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This investigation characterized venous endothelial healing after surgical manipulation. Procedures were performed on jugular and femoral veins in 21 mongrel dogs without systemic anticoagulation. Veins were harvested at varying intervals and vessel structure evaluated with light, transmission, and scanning electron microscopy. Veins that were mobilized or stripped of adventitia demonstrated 25% to 50% endothelial loss at one hour. Endothelial damage was rapidly repaired with complete healing observed in some veins at 48 hours. Tourniquet and clamps resulted in prominent medial and endothelial injury at occlusion sites. Eighteen of 24 transected veins remained patent for the study period. Endothelial healing was unaffected by tension at anastomoses. These observations confirm that venous endothelium receives nutrition by luminal diffusion. The healing process of venous anastomoses is characterized by an early fibrin sleeve sealing the anastomotic site; endothelial bridging of defects can be noticeably delayed by excessive fibrin deposition.

Original languageEnglish (US)
Pages (from-to)1240-1248
Number of pages9
JournalArchives of Surgery
Volume114
Issue number11
StatePublished - 1979

Fingerprint

Veins
Wounds and Injuries
Fibrin
Adventitia
Tourniquets
Scanning Transmission Electron Microscopy
Femoral Vein
Jugular Veins
Endothelium
Dogs
Light

ASJC Scopus subject areas

  • Surgery

Cite this

Krupski, W., Thal, E. R., Gewertz, B. L., Buja, L. M., Murphy, M. E., Hagler, H. K., & Fry, W. J. (1979). Endothelial response to venous injury. Archives of Surgery, 114(11), 1240-1248.

Endothelial response to venous injury. / Krupski, W.; Thal, E. R.; Gewertz, B. L.; Buja, L. M.; Murphy, M. E.; Hagler, H. K.; Fry, W. J.

In: Archives of Surgery, Vol. 114, No. 11, 1979, p. 1240-1248.

Research output: Contribution to journalArticle

Krupski, W, Thal, ER, Gewertz, BL, Buja, LM, Murphy, ME, Hagler, HK & Fry, WJ 1979, 'Endothelial response to venous injury', Archives of Surgery, vol. 114, no. 11, pp. 1240-1248.
Krupski W, Thal ER, Gewertz BL, Buja LM, Murphy ME, Hagler HK et al. Endothelial response to venous injury. Archives of Surgery. 1979;114(11):1240-1248.
Krupski, W. ; Thal, E. R. ; Gewertz, B. L. ; Buja, L. M. ; Murphy, M. E. ; Hagler, H. K. ; Fry, W. J. / Endothelial response to venous injury. In: Archives of Surgery. 1979 ; Vol. 114, No. 11. pp. 1240-1248.
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