Endothelial signaling during development

Ondine Cleaver; Douglas A. Melton

doi:10.1038/nm0603-661

Endothelial signaling during development

Ondine Cleaver, Douglas A. Melton

Research output: Contribution to journal › Review article › peer-review

438 Scopus citations

Abstract

Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between tissues and blood. Increasing evidence, however, points to a direct role for paracrine signaling between blood vessel cells and surrounding target organ cells, during embryonic development and cell differentiation. Understanding the nature of this signaling and its heterogeneity, both in the embryo and in adult tissues, may not only provide insights into mechanisms for normal developmental cell fate decisions, but could also lead to novel targeted therapeutic approaches for a variety of diseases such as heart disease, diabetes or cancer.

Original language	English (US)
Pages (from-to)	661-668
Number of pages	8
Journal	Nature medicine
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/nm0603-661
State	Published - Jun 1 2003

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm0603-661

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title = "Endothelial signaling during development",

abstract = "Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between tissues and blood. Increasing evidence, however, points to a direct role for paracrine signaling between blood vessel cells and surrounding target organ cells, during embryonic development and cell differentiation. Understanding the nature of this signaling and its heterogeneity, both in the embryo and in adult tissues, may not only provide insights into mechanisms for normal developmental cell fate decisions, but could also lead to novel targeted therapeutic approaches for a variety of diseases such as heart disease, diabetes or cancer.",

author = "Ondine Cleaver and Melton, {Douglas A.}",

note = "Funding Information: We thank Y. Dor and R. Lee for critical reading of the manuscript, and E. Lammert for useful discussions. O.C. is supported by the Howard Hughes Medical Institute and D.A.M. is an investigator of the Howard Hughes Medical Institute.",

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N2 - Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between tissues and blood. Increasing evidence, however, points to a direct role for paracrine signaling between blood vessel cells and surrounding target organ cells, during embryonic development and cell differentiation. Understanding the nature of this signaling and its heterogeneity, both in the embryo and in adult tissues, may not only provide insights into mechanisms for normal developmental cell fate decisions, but could also lead to novel targeted therapeutic approaches for a variety of diseases such as heart disease, diabetes or cancer.

AB - Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between tissues and blood. Increasing evidence, however, points to a direct role for paracrine signaling between blood vessel cells and surrounding target organ cells, during embryonic development and cell differentiation. Understanding the nature of this signaling and its heterogeneity, both in the embryo and in adult tissues, may not only provide insights into mechanisms for normal developmental cell fate decisions, but could also lead to novel targeted therapeutic approaches for a variety of diseases such as heart disease, diabetes or cancer.

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Endothelial signaling during development

Abstract

ASJC Scopus subject areas

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