Endothelin-1 depolarizes a ventral root potential in the newborn rat spinal cord

T. Yoshizawa, S. Kimura, I. Kanazawa, Masashi Yanagisawa, T. Masaki

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The effect of endothelin-1 (ET-1) was investigated in the isolated spinal cord of the newborn rat. Bath-applied ET-1 produced a depolarization of a lumbar ventral root, which was suppressed by nicardipine or a substance P antagonist (spantide). In addition, the slow ventral root depolarization from L4 segment evoked by electrical stimulation of the contralateral sciatic nerve was also suppressed by spantide or nicardipine. However, nicardipine did not affect the ventral root depolarization induced by substance P, itself. These results indicate that the dihydropyridine-sensitive Ca2+ channels are associated with substance P release and that the effect of endothelin is probably mediated by substance P.

Original languageEnglish (US)
Pages (from-to)S216-S217
JournalJournal of Cardiovascular Pharmacology
StatePublished - 1989


  • Contralateral slow ventral root potential
  • Dihydropyridine-sensitive Ca channel
  • ET-1
  • Nicardipine
  • Spinal cord
  • Substance P

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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