TY - JOUR
T1 - Endothelin converting enzyme-1 expression in endometrial adenocarcinomas
AU - Arun, Banu
AU - Kilic, Gokhan
AU - Ashfaq, Raheela
AU - Saboorian, Hossein M.
AU - Gokaslan, Tunc
PY - 2001
Y1 - 2001
N2 - Endothelin-1 (ET-1) is a potent mitogen in various precursor tumor cells, including endometrial adenocarcinoma. It is proposed that ET-1 produced by endometrial adenocarcinoma may participate in the angiogenesis of this carcinoma in vivo. Endothelin converting enzyme-1 (ECE-1) is the key enzyme that synthesizes ET-1. In this study, we tried to demonstrate the expression of ECE-1 in endometrial carcinomas. Deparaffinized tissue sections from patients with endometrial adenocarcinoma were analyzed by immunohistochemistry for the presence of ECE-1. Our study showed that the expression of ECE-1 was markedly increased in 9 of 15 (60%) well-differentiated endometrial adenocarcinomas; in contrast, only 2 out of 10 (20%) control specimens showed a mild labeling. With new selective inhibitory molecules emerging, research is currently evaluating the possible inhibition of ECE-1 as an alternative approach for the treatment of endometrial as well as other carcinomas.
AB - Endothelin-1 (ET-1) is a potent mitogen in various precursor tumor cells, including endometrial adenocarcinoma. It is proposed that ET-1 produced by endometrial adenocarcinoma may participate in the angiogenesis of this carcinoma in vivo. Endothelin converting enzyme-1 (ECE-1) is the key enzyme that synthesizes ET-1. In this study, we tried to demonstrate the expression of ECE-1 in endometrial carcinomas. Deparaffinized tissue sections from patients with endometrial adenocarcinoma were analyzed by immunohistochemistry for the presence of ECE-1. Our study showed that the expression of ECE-1 was markedly increased in 9 of 15 (60%) well-differentiated endometrial adenocarcinomas; in contrast, only 2 out of 10 (20%) control specimens showed a mild labeling. With new selective inhibitory molecules emerging, research is currently evaluating the possible inhibition of ECE-1 as an alternative approach for the treatment of endometrial as well as other carcinomas.
KW - Endometrial cancer
KW - Endothelin converting enzyme-1
UR - http://www.scopus.com/inward/record.url?scp=0035216116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035216116&partnerID=8YFLogxK
U2 - 10.1081/CNV-100107738
DO - 10.1081/CNV-100107738
M3 - Article
C2 - 11768030
AN - SCOPUS:0035216116
SN - 0735-7907
VL - 19
SP - 779
EP - 782
JO - Cancer Investigation
JF - Cancer Investigation
IS - 8
ER -