Endothelin-secreting tumor

K. Yokokawa, H. Tahara, M. Kohno, K. Murakawa -i., K. Yasunari, K. Nakagawa, T. Hamada, S. Otani, M. Yanagisawa, T. Takeda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Recently, we have reported two cases with endothelin (ET)-secreting tumor presenting with hypertension and elevated plasma endothelin-1 (ET-1) levels. The present study examines the histopathology of the ET-secreting tumor in one of these cases. The neoplasm was located in the skin and microscopically characterized as a malignant hemangioendothelioma by remarkable intravascular proliferations of atypical endothelium with the expression of Factor VIII-related antigen in the tumor cells. The tumor enlarged rapidly with rising ET-1 and blood pressure levels. The ET-1 content and its messenger RNA expression in the tumor extract were higher than those from normal parts of skin. ET-1 may play a pathophysiological role in patients with ET-secreting malignant hemangioendothelioma.

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Volume17
Issue numberSUPPL. 7
StatePublished - 1991

Fingerprint

Endothelins
Endothelin-1
Hemangioendothelioma
Neoplasms
Skin
von Willebrand Factor
Endothelium
Blood Pressure
Hypertension
Messenger RNA

Keywords

  • Endothelin-1
  • Endothelin-1 mRNA
  • Histopathology
  • Hypertension
  • Malignant hemangioendothelioma
  • Skin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Yokokawa, K., Tahara, H., Kohno, M., Murakawa -i., K., Yasunari, K., Nakagawa, K., ... Takeda, T. (1991). Endothelin-secreting tumor. Journal of Cardiovascular Pharmacology, 17(SUPPL. 7).

Endothelin-secreting tumor. / Yokokawa, K.; Tahara, H.; Kohno, M.; Murakawa -i., K.; Yasunari, K.; Nakagawa, K.; Hamada, T.; Otani, S.; Yanagisawa, M.; Takeda, T.

In: Journal of Cardiovascular Pharmacology, Vol. 17, No. SUPPL. 7, 1991.

Research output: Contribution to journalArticle

Yokokawa, K, Tahara, H, Kohno, M, Murakawa -i., K, Yasunari, K, Nakagawa, K, Hamada, T, Otani, S, Yanagisawa, M & Takeda, T 1991, 'Endothelin-secreting tumor', Journal of Cardiovascular Pharmacology, vol. 17, no. SUPPL. 7.
Yokokawa K, Tahara H, Kohno M, Murakawa -i. K, Yasunari K, Nakagawa K et al. Endothelin-secreting tumor. Journal of Cardiovascular Pharmacology. 1991;17(SUPPL. 7).
Yokokawa, K. ; Tahara, H. ; Kohno, M. ; Murakawa -i., K. ; Yasunari, K. ; Nakagawa, K. ; Hamada, T. ; Otani, S. ; Yanagisawa, M. ; Takeda, T. / Endothelin-secreting tumor. In: Journal of Cardiovascular Pharmacology. 1991 ; Vol. 17, No. SUPPL. 7.
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AU - Yasunari, K.

AU - Nakagawa, K.

AU - Hamada, T.

AU - Otani, S.

AU - Yanagisawa, M.

AU - Takeda, T.

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AB - Recently, we have reported two cases with endothelin (ET)-secreting tumor presenting with hypertension and elevated plasma endothelin-1 (ET-1) levels. The present study examines the histopathology of the ET-secreting tumor in one of these cases. The neoplasm was located in the skin and microscopically characterized as a malignant hemangioendothelioma by remarkable intravascular proliferations of atypical endothelium with the expression of Factor VIII-related antigen in the tumor cells. The tumor enlarged rapidly with rising ET-1 and blood pressure levels. The ET-1 content and its messenger RNA expression in the tumor extract were higher than those from normal parts of skin. ET-1 may play a pathophysiological role in patients with ET-secreting malignant hemangioendothelioma.

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