Endotoxin concentrations in cerebrospinal fluid correlate with clinical severity and neurologic outcome of Haemophilus influenzae type B meningitis

J. Mertsola, W. A. Kennedy, D. Waagner, X. Saez-Llorens, K. Olsen, E. J. Hansen, G. H. McCracken

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Abstract

Endotoxin concentrations were measured in paired samples of cerebrospinal fluid from 38 patients with Haemophilus influenzae type b meningitis. On admission, the median concentration of endotoxin in cerebrospinal fluid was 104 ng/mL and decreased rapidly in follow-up samples. From 17 to 48 hours after admission, 50% of the patients had concentrations of less than 1 ng/mL. Endotoxin concentrations correlated significantly with concentrations of interleukin 1β, protein, and glucose in cerebrospinal fluid, duration of secondary fever, and neurologic abnormalities during hospitalization and on follow-up examinations. Twenty-eight percent of patients with endotoxin concentrations of 100 ng/mL or more on admission had long-term complications, compared with none of those with lower endotoxin concentrations (relative risk, 2.31; 95% confidence interval, 1.53 to 3.48). These results indicate that quantitation of endotoxin in cerebrospinal fluid could be a valuable aid in identifying those children at increased risk of complications during Haemophilus influenzae type b meningitis and provide additional evidence that the Haemophilus influenzae type b meningitis lipo-oligosaccharide is important in the pathogenesis of meningitis.

Original languageEnglish (US)
Pages (from-to)1099-1103
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume145
Issue number10
StatePublished - 1991

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Haemophilus Meningitis
Endotoxins
Nervous System
Cerebrospinal Fluid
Meningitis
Haemophilus influenzae type b
Nervous System Malformations
Patient Admission
Oligosaccharides
Interleukin-1
Hospitalization
Fever
Confidence Intervals
Glucose

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Endotoxin concentrations in cerebrospinal fluid correlate with clinical severity and neurologic outcome of Haemophilus influenzae type B meningitis. / Mertsola, J.; Kennedy, W. A.; Waagner, D.; Saez-Llorens, X.; Olsen, K.; Hansen, E. J.; McCracken, G. H.

In: American Journal of Diseases of Children, Vol. 145, No. 10, 1991, p. 1099-1103.

Research output: Contribution to journalArticle

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AU - Kennedy, W. A.

AU - Waagner, D.

AU - Saez-Llorens, X.

AU - Olsen, K.

AU - Hansen, E. J.

AU - McCracken, G. H.

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