TY - JOUR
T1 - Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity
AU - Beutler, Bruce
PY - 2000/2/1
Y1 - 2000/2/1
N2 - Positional cloning work and subsequent biochemical analyses have revealed that Toll-like receptor 4 (Tlr4) transduces the lipopolysaccharide (LPS) signal, alerting the host to infection by Gram-negative bacteria. Moreover, it appears that the LPS sensing pathway is a solitary one: disruption of Tlr4 causes complete unresponsiveness to LPS. As several Tlr family members exist in vertebrates, it appears likely that the innate immune system defends the host by recognizing a small number of structurally conserved molecules that distinguish the microbial world from tissues of the host.
AB - Positional cloning work and subsequent biochemical analyses have revealed that Toll-like receptor 4 (Tlr4) transduces the lipopolysaccharide (LPS) signal, alerting the host to infection by Gram-negative bacteria. Moreover, it appears that the LPS sensing pathway is a solitary one: disruption of Tlr4 causes complete unresponsiveness to LPS. As several Tlr family members exist in vertebrates, it appears likely that the innate immune system defends the host by recognizing a small number of structurally conserved molecules that distinguish the microbial world from tissues of the host.
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U2 - 10.1016/S1369-5274(99)00046-6
DO - 10.1016/S1369-5274(99)00046-6
M3 - Review article
C2 - 10679425
AN - SCOPUS:0033968116
SN - 1369-5274
VL - 3
SP - 23
EP - 28
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 1
ER -