Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase

Medicine & Life Sciences

• tyrosyl-DNA phosphodiesterase 100%
• Phosphodiesterase I 88%
• Folic Acid Antagonists 76%
• Thymidylate Synthase 73%
• Camptothecin 72%
• Type I DNA Topoisomerase 28%
• Bone Marrow Cells 15%
• Drug Resistance 15%
• DNA Fragmentation 11%
• Enzymes 9%
• Genes 8%
• Topoisomerase I Inhibitors 7%
• Comet Assay 6%
• Retroviridae 5%
• Cytotoxic T-Lymphocytes 5%
• Cricetulus 5%
• Drug Combinations 5%
• Duration of Therapy 5%
• Immunotherapy 4%
• Pharmaceutical Preparations 4%
• Therapeutics 4%
• Complementary DNA 4%
• Poisons 4%
• Fibroblasts 4%
• Stem Cells 4%
• Escherichia coli 3%
• Neoplasms 3%
• Drug Therapy 3%
• Lung 2%

Chemical Compounds

• Antifolate 80%
• Camptothecin 70%
• Resistance 34%
• Thymidylate Synthase Inhibitor 15%
• Comet Assay 12%
• Drug 9%
• Complementary DNA 9%
• Mammalian Cell 9%
• Toxic 6%