'Engineering' the wound-healing process: The association of chitosan- mediated inhibition of wound-model contraction with inhibition of gap junctions

Muthumarthanda R. Mariappan, John G. Williams, Morton D. Prager, Robert C. Eberhart

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The final stage in dermal wound healing following burn or trauma involves remodeling the granulation tissue. This stage also takes into account the possibility of wound contraction. Functional disregulation of wound contraction occurs in fibrotic diseases such as pathological contractures and scar formation. Controlling fibroblast transformation may enable useful engineering of the wound contraction response. The effects of various wound-healing agents on fibroblast behavior was studied. The study hypothesizes that the efficient contraction of the in vitro wound model is associated with gap junction formation between cells, and conversely, that inhibition of the in vitro wound-model contraction is associated with inhibition of GJ between cells.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalIEEE Engineering in Medicine and Biology Magazine
Volume18
Issue number6
DOIs
StatePublished - Nov 1 1999

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ASJC Scopus subject areas

  • Biomedical Engineering

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