Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells

Kwang Woon Kim, Pritha Paul, Jingbo Qiao, Sora Lee, Dai H. Chung

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

ACTB, actin beta; ATG, autophagy-related; BAFA1, bafilomycin A1; GRP, gastrin-releasing peptide; GRPR, gastrin-releasing peptide receptor; GFP-LC3, green fluorescent protein-microtubule-associated protein 1 light chain 3; NB, neuroblastoma; HUVECs, human umbilical vein endothelial cells; MTOR, mechanistic target of rapamycin; RPS6, ribosomal protein S6; SQSTM1/p62, sequestosome 1; v-ATPase, vacuolar-type H+-ATPase.

Original languageEnglish (US)
Pages (from-to)1579-1590
Number of pages12
JournalAutophagy
Volume9
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Angiogenesis
  • Autophagy
  • Endothelial cells
  • GRP
  • Neuroblastoma
  • Rapamycin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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