Enhanced multi-protocol analysis via intelligent supervised embedding (EMPrAvISE): Detecting prostate cancer on multi-parametric MRI

Satish Viswanath, B. Nicholas Bloch, Jonathan Chappelow, Pratik Patel, Neil Rofsky, Robert Lenkinski, Elizabeth Genega, Anant Madabhushi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

Currently, there is significant interest in developing methods for quantitative integration of multi-parametric (structural, functional) imaging data with the objective of building automated meta-classifiers to improve disease detection, diagnosis, and prognosis. Such techniques are required to address the differences in dimensionalities and scales of individual protocols, while deriving an integrated multi-parametric data representation which best captures all disease-pertinent information available. In this paper, we present a scheme called Enhanced Multi-Protocol Analysis via Intelligent Supervised Embedding (EMPrAvISE); a powerful, generalizable framework applicable to a variety of domains for multi-parametric data representation and fusion. Our scheme utilizes an ensemble of embeddings (via dimensionality reduction, DR); thereby exploiting the variance amongst multiple uncorrelated embeddings in a manner similar to ensemble classifier schemes (e.g. Bagging, Boosting). We apply this framework to the problem of prostate cancer (CaP) detection on 12 3 Tesla pre-operative in vivo multi-parametric (T2-weighted, Dynamic Contrast Enhanced, and Diffusion-weighted) magnetic resonance imaging (MRI) studies, in turn comprising a total of 39 2D planar MR images. We first align the different imaging protocols via automated image registration, followed by quantification of image attributes from individual protocols. Multiple embeddings are generated from the resultant high-dimensional feature space which are then combined intelligently to yield a single stable solution. Our scheme is employed in conjunction with graph embedding (for DR) and probabilistic boosting trees (PBTs) to detect CaP on multi-parametric MRI. Finally, a probabilistic pairwise Markov Random Field algorithm is used to apply spatial constraints to the result of the PBT classifier, yielding a per-voxel classification of CaP presence. Per-voxel evaluation of detection results against ground truth for CaP extent on MRI (obtained by spatially registering pre-operative MRI with available whole-mount histological specimens) reveals that EMPrAvISE yields a statistically significant improvement (AUC=0.77) over classifiers constructed from individual protocols (AUC=0.62, 0.62, 0.65, for T2w, DCE, DWI respectively) as well as one trained using multi-parametric feature concatenation (AUC=0.67).

Original languageEnglish (US)
Title of host publicationMedical Imaging 2011
Subtitle of host publicationComputer-Aided Diagnosis
DOIs
StatePublished - May 13 2011
EventMedical Imaging 2011: Computer-Aided Diagnosis - Lake Buena Vista, FL, United States
Duration: Feb 15 2011Feb 17 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7963
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2011: Computer-Aided Diagnosis
CountryUnited States
CityLake Buena Vista, FL
Period2/15/112/17/11

Keywords

  • 3 Tesla
  • CAD
  • DCE-MRI
  • DWI-MRI
  • T2w MRI
  • ensemble embedding
  • multi-modal integration
  • multi-parametric
  • multi-protocol
  • non-rigid registration
  • probabilistic boosting trees
  • prostate cancer
  • supervised learning

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Viswanath, S., Bloch, B. N., Chappelow, J., Patel, P., Rofsky, N., Lenkinski, R., Genega, E., & Madabhushi, A. (2011). Enhanced multi-protocol analysis via intelligent supervised embedding (EMPrAvISE): Detecting prostate cancer on multi-parametric MRI. In Medical Imaging 2011: Computer-Aided Diagnosis [79630U] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7963). https://doi.org/10.1117/12.878312