Enhanced production of human interferon-gamma by the use of a combination of inducers--phytohemagglutinin, picibanil and tumor promoting agent.

J. T. Hsieh, C. K. Ho, R. J. Perng, H. Y. Chen, C. H. Yung

Research output: Contribution to journalArticle

Abstract

Phytohemagglutinin (PHA), picibanil (OK432) and tumor promoting agent (TPA) were tested in various combinations for optimal induction of human interferon-gamma (HuIFN-gamma). It was found that the use of a mixture of all 3 inducers resulted in IFN production 2-3 times higher than either PHA (10 micrograms/ml) in combination with TPA (5 ng/ml) or picibanil (10 micrograms/ml) alone. The IFN was produced by T lymphocytes and could be neutralized by specific IFN-gamma antiserum. It was pH 2.0 labile and species specific.

Original languageEnglish (US)
Pages (from-to)311-313
Number of pages3
JournalProceedings of the National Science Council, Republic of China. Part B, Life sciences
Volume9
Issue number4
StatePublished - Oct 1985

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Picibanil
Phytohemagglutinins
Immune Sera
Neoplasms
T-Lymphocytes
human IFNG protein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Phytohemagglutinin (PHA), picibanil (OK432) and tumor promoting agent (TPA) were tested in various combinations for optimal induction of human interferon-gamma (HuIFN-gamma). It was found that the use of a mixture of all 3 inducers resulted in IFN production 2-3 times higher than either PHA (10 micrograms/ml) in combination with TPA (5 ng/ml) or picibanil (10 micrograms/ml) alone. The IFN was produced by T lymphocytes and could be neutralized by specific IFN-gamma antiserum. It was pH 2.0 labile and species specific.",
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AU - Hsieh, J. T.

AU - Ho, C. K.

AU - Perng, R. J.

AU - Chen, H. Y.

AU - Yung, C. H.

PY - 1985/10

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N2 - Phytohemagglutinin (PHA), picibanil (OK432) and tumor promoting agent (TPA) were tested in various combinations for optimal induction of human interferon-gamma (HuIFN-gamma). It was found that the use of a mixture of all 3 inducers resulted in IFN production 2-3 times higher than either PHA (10 micrograms/ml) in combination with TPA (5 ng/ml) or picibanil (10 micrograms/ml) alone. The IFN was produced by T lymphocytes and could be neutralized by specific IFN-gamma antiserum. It was pH 2.0 labile and species specific.

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