Enhanced regulatory T cell activity is an element of the host response to injury

Niamh Ni Choileain, Malcolm MacConmara, Yan Zang, Thomas J. Murphy, John A. Mannick, James A. Lederer

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

CD4+CD25+ regulatory T cells (Tregs) play a critical role in suppressing the development of autoimmune disease, in controlling potentially harmful inflammatory responses, and in maintaining immune homeostasis. Because severe injury triggers both excessive inflammation and suppressed adaptive immunity, we wished to test whether injury could influence Treg activity. Using a mouse burn injury model, we demonstrate that injury significantly enhances Treg function. This increase in Treg activity is apparent at 7 days after injury and is restricted to lymph node CD4+CD25 + T cells draining the injury site. Moreover, we show that this injury-induced increase in Treg activity is cell-contact dependent and is mediated in part by increased cell surface TGF-β1 expression. To test the in vivo significance of these findings, mice were depleted of CD4 +CD25+ T cells before sham or burn injury and then were immunized to follow the development of T cell-dependent Ag-specific immune reactivity. We observed that injured mice, which normally demonstrate suppressed Th1-type immunity, showed normal Th1 responses when depleted of CD4 +CD25+ T cells. Taken together, these observations suggest that injury can induce or amplify CD4+CD25+ Treg function and that CD4+CD25+ T cells contribute to the development of postinjury immune suppression.

Original languageEnglish (US)
Pages (from-to)225-236
Number of pages12
JournalJournal of Immunology
Volume176
Issue number1
StatePublished - Jan 1 2006

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Response Elements
Regulatory T-Lymphocytes
Wounds and Injuries
T-Lymphocytes
Adaptive Immunity
Autoimmune Diseases
Immunity
Homeostasis
Lymph Nodes
Inflammation

ASJC Scopus subject areas

  • Immunology

Cite this

Choileain, N. N., MacConmara, M., Zang, Y., Murphy, T. J., Mannick, J. A., & Lederer, J. A. (2006). Enhanced regulatory T cell activity is an element of the host response to injury. Journal of Immunology, 176(1), 225-236.

Enhanced regulatory T cell activity is an element of the host response to injury. / Choileain, Niamh Ni; MacConmara, Malcolm; Zang, Yan; Murphy, Thomas J.; Mannick, John A.; Lederer, James A.

In: Journal of Immunology, Vol. 176, No. 1, 01.01.2006, p. 225-236.

Research output: Contribution to journalArticle

Choileain, NN, MacConmara, M, Zang, Y, Murphy, TJ, Mannick, JA & Lederer, JA 2006, 'Enhanced regulatory T cell activity is an element of the host response to injury', Journal of Immunology, vol. 176, no. 1, pp. 225-236.
Choileain NN, MacConmara M, Zang Y, Murphy TJ, Mannick JA, Lederer JA. Enhanced regulatory T cell activity is an element of the host response to injury. Journal of Immunology. 2006 Jan 1;176(1):225-236.
Choileain, Niamh Ni ; MacConmara, Malcolm ; Zang, Yan ; Murphy, Thomas J. ; Mannick, John A. ; Lederer, James A. / Enhanced regulatory T cell activity is an element of the host response to injury. In: Journal of Immunology. 2006 ; Vol. 176, No. 1. pp. 225-236.
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