Enhancement of immunoglobulin and rheumatoid factor synthesis by rheumatoid synovial effusions and synovial membrane culture supernatants

M. Rosenthal, P. Stastny, M. Ziff

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Rheumatoid joint effusions and rheumatoid synovial membrane supernatants contain factors capable of enhancing immunoglobulin synthesis in normal and rheumatoid lymphocytes. A low molecular weight nonspecific enhancing factor which stimulates immunoglobulin synthesis in both normal and rheumatoid lymphocytes is present in fraction V from agarose A 5m of rheumatoid effusions. It has the size of a lymphokine like mediator of T cell function. A high molecular enhancing factor containing IgG and IgM is present in fraction II of rheumatoid effusions which stimulates immunoglobulin synthesis only in rheumatoid lymphocytes. Rheumatoid factor production is also enhanced by fractions II and V, but only in rheumatoid lymphocyte cultures. Rheumatoid lymphocytes react more intensely to the nonspecific enhancing factor present in fraction V. These findings demonstrate a possible pathway whereby cellular immune mechanisms may influence the humoral immune response in rheumatoid arthritis.

Original languageEnglish (US)
Title of host publicationRHEUM.ANNUAL REV.
Pages87-89
Number of pages3
VolumeVol. 6
StatePublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Enhancement of immunoglobulin and rheumatoid factor synthesis by rheumatoid synovial effusions and synovial membrane culture supernatants'. Together they form a unique fingerprint.

  • Cite this

    Rosenthal, M., Stastny, P., & Ziff, M. (1975). Enhancement of immunoglobulin and rheumatoid factor synthesis by rheumatoid synovial effusions and synovial membrane culture supernatants. In RHEUM.ANNUAL REV. (Vol. Vol. 6, pp. 87-89)