Enhancement of in vitro transformation by polyinosinic-polycytidylic acid

P. J. Price, W. A. Suk, M. Zimmerman, G. J. Spahn, A. F. Gazdar, S. Bacon

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The synthetic, double-stranded RNA, polyinosinic-polycytidylic acid (poly I: C), under certain conditions acted as a transforming agent. Low-passage Fischer rat-embryo cells were transformed when poly I: C was added to cells newly infected with Rauscher murine leukemia virus (RLV). Poly I: C had no transforming effect when added to virus-free cultures or to the low-passage cells chronically infected with RLV. High-passage Fischer rat-embryo cells were transformed by poly I: C in either the absence or presence of RLV. The findings indicated that further studies are needed on the possible oncogenic potential of poly I: C.—J Natl Cancer Inst 50: 1299-1305, 1973.

Original languageEnglish (US)
Pages (from-to)1299-1305
Number of pages7
JournalJournal of the National Cancer Institute
Volume50
Issue number5
DOIs
StatePublished - May 1973

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Price, P. J., Suk, W. A., Zimmerman, M., Spahn, G. J., Gazdar, A. F., & Bacon, S. (1973). Enhancement of in vitro transformation by polyinosinic-polycytidylic acid. Journal of the National Cancer Institute, 50(5), 1299-1305. https://doi.org/10.1093/jnci/50.5.1299