@article{40068ec24f1145b390656475de384043,
title = "Enhancement of in vitro transformation by polyinosinic-polycytidylic acid",
abstract = "The synthetic, double-stranded RNA, polyinosinic-polycytidylic acid (poly I: C), under certain conditions acted as a transforming agent. Low-passage Fischer rat-embryo cells were transformed when poly I: C was added to cells newly infected with Rauscher murine leukemia virus (RLV). Poly I: C had no transforming effect when added to virus-free cultures or to the low-passage cells chronically infected with RLV. High-passage Fischer rat-embryo cells were transformed by poly I: C in either the absence or presence of RLV. The findings indicated that further studies are needed on the possible oncogenic potential of poly I: C.—J Natl Cancer Inst 50: 1299-1305, 1973.",
author = "Price, {P. J.} and Suk, {W. A.} and M. Zimmerman and Spahn, {G. J.} and Gazdar, {A. F.} and S. Bacon",
note = "Funding Information: Experimental procedure.-With the virus-inoculated F-lll cultures, poly I: C treatment was started 24 hours before inoculation with RLV. In the first experiment, the virus was received from Dr. Hartley as Pool AP50 RLV, and the subsequent virus pools had a titer of IOU/ml. In the second experiment, it was obtained from the filtered supernatant 1 Received October 19, 1972; accepted January 12, 1973. 2 Study conducted under Public Health Service contract NIH-70-2068 within the Special Virus-Cancer Program of the National Cancer Institute. S National Cancer Institute. 4 National Institute for Allergy and Infectious Diseases. 5 National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare.",
year = "1973",
month = may,
doi = "10.1093/jnci/50.5.1299",
language = "English (US)",
volume = "50",
pages = "1299--1305",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "5",
}