Enhancing executive function and neural health in bipolar disorder through reasoning training

Erin E. Venza, Sandra B. Chapman, Sina Aslan, Jennifer E. Zientz, David L. Tyler, Jeffrey S. Spence

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cognitive deficits in executive function and memory among individuals with bipolar disorder (BD) are well-documented; however, only recently have efforts begun to address whether such cognitive deficits can be ameliorated through cognitive training. This pilot study examined the effects of a top-down, cognitive reasoning training program in adults with BD on both brain and cognitive measures. Twenty-seven participants (11 males, 16 females), aged 21-70 years old, completed the study. Participants completed neurocognitive testing and functional magnetic resonance imaging (fMRI) before and after training, consisting of 8 h (2 h/week) of training in small groups. The training delivered information processing strategies that were implemented and applicable to a variety of daily living contexts. Results indicated that participants showed significant gains in the primary outcome measure of complex abstraction, also referred to as gist reasoning, as well as in untrained domains of executive function and memory. We found a significant increase in resting cerebral blood flow (CBF) in left inferior frontal gyrus after cognitive training. We also found that resting CBF in the right frontal middle gyrus correlated positively with performance on the measure of complex abstraction. This feasibility study provides promising evidence that short-term reasoning training can enhance cognitive performance and brain health in adults with BD. These data motivate further efforts to explore adjuvant therapeutics to improve cognitive performance and underlying brain systems in bipolar, as well as other psychiatric disorders.

Original languageEnglish (US)
Article number1676
JournalFrontiers in Psychology
Volume7
Issue numberNOV
DOIs
StatePublished - Nov 1 2016

Fingerprint

Executive Function
Cerebrovascular Circulation
Bipolar Disorder
Health
Brain
Feasibility Studies
Prefrontal Cortex
Automatic Data Processing
Psychiatry
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Education
Therapeutics

Keywords

  • Bipolar disorder
  • Cerebral blood flow
  • Cognition
  • Cognitive training
  • Executive function
  • Frontal networks
  • Memory

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Venza, E. E., Chapman, S. B., Aslan, S., Zientz, J. E., Tyler, D. L., & Spence, J. S. (2016). Enhancing executive function and neural health in bipolar disorder through reasoning training. Frontiers in Psychology, 7(NOV), [1676]. https://doi.org/10.3389/fpsyg.2016.01676

Enhancing executive function and neural health in bipolar disorder through reasoning training. / Venza, Erin E.; Chapman, Sandra B.; Aslan, Sina; Zientz, Jennifer E.; Tyler, David L.; Spence, Jeffrey S.

In: Frontiers in Psychology, Vol. 7, No. NOV, 1676, 01.11.2016.

Research output: Contribution to journalArticle

Venza, EE, Chapman, SB, Aslan, S, Zientz, JE, Tyler, DL & Spence, JS 2016, 'Enhancing executive function and neural health in bipolar disorder through reasoning training', Frontiers in Psychology, vol. 7, no. NOV, 1676. https://doi.org/10.3389/fpsyg.2016.01676
Venza, Erin E. ; Chapman, Sandra B. ; Aslan, Sina ; Zientz, Jennifer E. ; Tyler, David L. ; Spence, Jeffrey S. / Enhancing executive function and neural health in bipolar disorder through reasoning training. In: Frontiers in Psychology. 2016 ; Vol. 7, No. NOV.
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