Enhancing motor performance improvement by personalizing non-invasive cortical stimulation with concurrent functional near-infrared spectroscopy and multi-modal motor measurements

Bilal Khan, Timea Hodics, Nathan Hervey, George Kondraske, Ann Stowe, George Alexandrakis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive cortical stimulation technique that can facilitate task specific plasticity that can improve motor performance. Current tDCS interventions uniformly apply a chosen electrode montage to a subject population without personalizing electrode placement for optimal motor gains. We propose a novel perturbation tDCS (ptDCS) paradigm for determining a personalized electrode montage in which tDCS intervention yields maximal motor performance improvements during stimulation. PtDCS was applied to ten healthy adults and five stroke patients with upper hemiparesis as they performed an isometric wrist flexion task with their non-dominant arm. Simultaneous recordings of torque applied to a stationary handle, muscle activity by electromyography (EMG), and cortical activity by functional near-infrared spectroscopy (fNIRS) during ptDCS helped interpret how cortical activity perturbations by any given electrode montage related to changes in muscle activity and task performance quantified by a Reaction Time (RT) X Error product. PtDCS enabled quantifying the effect on task performance of 20 different electrode pair montages placed over the sensorimotor cortex. Interestingly, the electrode montage maximizing performance in all healthy adults did not match any of the ones being explored in current literature as a means of improving the motor performance of stroke patients. Furthermore, the optimal montage was found to be different in each stroke patient and the resulting motor gains were very significant during stimulation. This study supports the notion that task-specific ptDCS optimization can lend itself to personalizing the rehabilitation of patients with brain injury.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9305
ISBN (Print)9781628413953
DOIs
StatePublished - 2015
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II - San Francisco, United States
Duration: Feb 7 2015Feb 10 2015

Other

OtherOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
CountryUnited States
CitySan Francisco
Period2/7/152/10/15

Fingerprint

Near infrared spectroscopy
Near-Infrared Spectroscopy
stimulation
Electrodes
infrared spectroscopy
electrodes
strokes
direct current
Stroke
Task Performance and Analysis
perturbation
Muscle
muscles
electromyography
Electromyography
Muscles
brain damage
wrist
Torque
Paresis

Keywords

  • functional imaging
  • near-infrared
  • non-invasive cortical stimulation
  • personalized therapy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Khan, B., Hodics, T., Hervey, N., Kondraske, G., Stowe, A., & Alexandrakis, G. (2015). Enhancing motor performance improvement by personalizing non-invasive cortical stimulation with concurrent functional near-infrared spectroscopy and multi-modal motor measurements. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9305). [93051A] SPIE. https://doi.org/10.1117/12.2076590

Enhancing motor performance improvement by personalizing non-invasive cortical stimulation with concurrent functional near-infrared spectroscopy and multi-modal motor measurements. / Khan, Bilal; Hodics, Timea; Hervey, Nathan; Kondraske, George; Stowe, Ann; Alexandrakis, George.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9305 SPIE, 2015. 93051A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Khan, B, Hodics, T, Hervey, N, Kondraske, G, Stowe, A & Alexandrakis, G 2015, Enhancing motor performance improvement by personalizing non-invasive cortical stimulation with concurrent functional near-infrared spectroscopy and multi-modal motor measurements. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9305, 93051A, SPIE, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2076590
Khan B, Hodics T, Hervey N, Kondraske G, Stowe A, Alexandrakis G. Enhancing motor performance improvement by personalizing non-invasive cortical stimulation with concurrent functional near-infrared spectroscopy and multi-modal motor measurements. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9305. SPIE. 2015. 93051A https://doi.org/10.1117/12.2076590
Khan, Bilal ; Hodics, Timea ; Hervey, Nathan ; Kondraske, George ; Stowe, Ann ; Alexandrakis, George. / Enhancing motor performance improvement by personalizing non-invasive cortical stimulation with concurrent functional near-infrared spectroscopy and multi-modal motor measurements. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9305 SPIE, 2015.
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