Enhancing solid phase synthesis by a noncovalent protection strategy - Efficient coupling of rhodamine to resin-bound peptide nucleic acids

Lynn D. Mayfield, David R. Corey

Research output: Contribution to journalArticle

18 Scopus citations


Resins for solid-phase synthesis can affect coupling efficiencies by interacting with reactants. We have observed that polyethylene glycol- polystyrene (PEG-PS) solid support absorbs added activated fluorophores, preventing efficient labeling of peptide nucleic acids (PNAs). We now report that addition of an inexpensive unactivated fluorophore blocks the resin and allows efficient labeling. This protection strategy may have general benefits for peptide and combinatorial synthesis.

Original languageEnglish (US)
Pages (from-to)1419-1422
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number10
StatePublished - May 17 1999


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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