Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging

Alison E. Baird, Andrew Benfield, Gottfried Schlaug, Bettina Siewert, Karl Olof Lövblad, Robert R. Edelman, Steven Warach

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Abstract

We aimed to determine the frequency and time course of the enlargement of ischemic cerebral lesions following human stroke and to study the effect of the state of perfusion on lesion enlargement. Acute lesion volumes were measured on diffusion-weighted magnetic resonance images and compared with lesion volumes measured on T2-weighted images at 7 days or later. Forty-four measurements were performed between 2 and 53 hours after stroke onset in 28 patients. Thirteen patients also had magnetic resonance perfusion imaging performed. In 12 (43%) of 28 patients the initial lesion volume increased by 20% or more. The number of studies showing enlargement of the ischemic lesion volume ranged from 12 (43%) of 28 at or after 2 hours to 10 (38%) of 26 at or after 6 hours, 5 (33%) of 15 at or after 24 hours, and 2 (33%) of 6 at or after 48 hours. In 7 of the 10 patients in whom the hypoperfusion volume acutely exceeded the volume of the abnormality on diffusion-weighted images, lesion volume increased by 20% or more. This study provided evidence that substantial enlargement of human cerebral ischemic lesion volumes can occur beyond the first 6, 12, or 24 hours after onset. A mismatch acutely between the region of hypoperfusion (larger) and the region of diffusion abnormality (smaller) may be predictive of ischemic lesion enlargement.

Original languageEnglish (US)
Pages (from-to)581-589
Number of pages9
JournalAnnals of Neurology
Volume41
Issue number5
DOIs
StatePublished - May 1997

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Diffusion Magnetic Resonance Imaging
Stroke
Magnetic Resonance Angiography
Magnetic Resonance Spectroscopy
Perfusion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Baird, A. E., Benfield, A., Schlaug, G., Siewert, B., Lövblad, K. O., Edelman, R. R., & Warach, S. (1997). Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Annals of Neurology, 41(5), 581-589. https://doi.org/10.1002/ana.410410506

Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. / Baird, Alison E.; Benfield, Andrew; Schlaug, Gottfried; Siewert, Bettina; Lövblad, Karl Olof; Edelman, Robert R.; Warach, Steven.

In: Annals of Neurology, Vol. 41, No. 5, 05.1997, p. 581-589.

Research output: Contribution to journalArticle

Baird, AE, Benfield, A, Schlaug, G, Siewert, B, Lövblad, KO, Edelman, RR & Warach, S 1997, 'Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging', Annals of Neurology, vol. 41, no. 5, pp. 581-589. https://doi.org/10.1002/ana.410410506
Baird, Alison E. ; Benfield, Andrew ; Schlaug, Gottfried ; Siewert, Bettina ; Lövblad, Karl Olof ; Edelman, Robert R. ; Warach, Steven. / Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. In: Annals of Neurology. 1997 ; Vol. 41, No. 5. pp. 581-589.
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