Enteric pathogens exploit the microbiota-generated nutritional environment of the gut

Alline R. Pacheco, Vanessa Sperandio

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Host bacterial associations have a profound impact on health and disease. The human gastrointestinal (GI) tract is inhabited by trillions of commensal bacteria that aid in the digestion of food and vitamin production and play crucial roles in human physiology. Disruption of these relationships and the structure of the bacterial communities that inhabit the gut can contribute to dysbiosis, leading to disease. This fundamental relationship between the host and microbiota relies on chemical signaling and nutrient availability and exchange. GI pathogens compete with the endogenous microbiota for a colonization niche (1, 2). The ability to monitor nutrients and combine this information with the host physiological state is important for the pathogen to precisely program the expression of its virulence repertoire. A major nutrient source is carbon, and although the impact of carbon nutrition on the colonization of the gut by the microbiota has been extensively studied, the extent to which carbon sources affect the regulation of virulence factors by invading pathogens has not been fully defined. The GI pathogen enterohemorrhagic E. coli (EHEC) gages sugar sources as an important cue to regulate expression of its virulence genes. EHEC senses whether it is in a gluconeogenic versus a glycolytic environment, as well as fluctuations of fucose levels to fine tune regulation of its virulence repertoire.

Original languageEnglish (US)
Article numberMBP-0001-2014
JournalMicrobiology spectrum
Volume3
Issue number3
DOIs
StatePublished - 2015

Fingerprint

Microbiota
virulence
pathogen
Enterohemorrhagic Escherichia coli
Virulence
Food
Carbon
carbon
colonization
Dysbiosis
health and disease
Bacterial Structures
commensal
Aptitude
Fucose
nutrient
Virulence Factors
vitamin
nutrient availability
Vitamins

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Microbiology (medical)
  • Ecology
  • Cell Biology
  • Genetics
  • Physiology

Cite this

Enteric pathogens exploit the microbiota-generated nutritional environment of the gut. / Pacheco, Alline R.; Sperandio, Vanessa.

In: Microbiology spectrum, Vol. 3, No. 3, MBP-0001-2014, 2015.

Research output: Contribution to journalArticle

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