TY - JOUR
T1 - Enterohemorrhagic Escherichia coli outwits hosts through sensing small molecules
AU - Carlson-Banning, Kimberly M.
AU - Sperandio, Vanessa
N1 - Funding Information:
This work was funded through National Institutes of Health grants T32AI007520 , AI053067 , and AI05135 .
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/2
Y1 - 2018/2
N2 - Small molecules help intestinal pathogens navigate the complex human gastrointestinal tract to exploit favorable microhabitats. These small molecules provide spatial landmarks for pathogens to regulate synthesis of virulence caches and are derived from the host, ingested plant and animal material, and the microbiota. Their concentrations and fluxes vary along the length of the gut and provide molecular signatures that are beginning to be explored through metabolomics and genetics. However, while many small molecules have been identified and are reviewed here, there are undoubtedly others that may also profoundly affect how enteric pathogens infect their hosts.
AB - Small molecules help intestinal pathogens navigate the complex human gastrointestinal tract to exploit favorable microhabitats. These small molecules provide spatial landmarks for pathogens to regulate synthesis of virulence caches and are derived from the host, ingested plant and animal material, and the microbiota. Their concentrations and fluxes vary along the length of the gut and provide molecular signatures that are beginning to be explored through metabolomics and genetics. However, while many small molecules have been identified and are reviewed here, there are undoubtedly others that may also profoundly affect how enteric pathogens infect their hosts.
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U2 - 10.1016/j.mib.2017.12.002
DO - 10.1016/j.mib.2017.12.002
M3 - Review article
C2 - 29258058
AN - SCOPUS:85038216022
SN - 1369-5274
VL - 41
SP - 83
EP - 88
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -