Enterohemorrhagic Escherichia coli outwits hosts through sensing small molecules

Kimberly M. Carlson-Banning, Vanessa Sperandio

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Small molecules help intestinal pathogens navigate the complex human gastrointestinal tract to exploit favorable microhabitats. These small molecules provide spatial landmarks for pathogens to regulate synthesis of virulence caches and are derived from the host, ingested plant and animal material, and the microbiota. Their concentrations and fluxes vary along the length of the gut and provide molecular signatures that are beginning to be explored through metabolomics and genetics. However, while many small molecules have been identified and are reviewed here, there are undoubtedly others that may also profoundly affect how enteric pathogens infect their hosts.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalCurrent Opinion in Microbiology
Volume41
DOIs
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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