Enzyme linked immunosorbent assay: determination of anti-adenovirus antibodies in an infant population.

A. Weinberg, M. C. Fink, S. Takimoto, M. A. Ishida, M. C. Souza

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

In order to define an accurate assay for anti-adenovirus antibody detection, a recently developed ELISA was compared with IFA and CF. On 58 sera, the ELISA was more sensitive than both CF and IFA, which showed relative sensitivities of 63% and 94%, respectively. It was not possible to determine the exact specificity of the tests because of the lack of a gold standard. Furthermore, the ELISA was used to define the prevalence of adenovirus antibodies in 116 infants between 1 and 24 months old (mean 7.28). The data showed that maternal antibodies waned by the age of 5 to 6 months and that more than 80% of the children had been infected by adenoviruses by the age of 10 months.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalRevista do Instituto de Medicina Tropical de São Paulo
Volume31
Issue number5
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Infectious Diseases

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