TY - JOUR
T1 - Enzyme linked immunosorbent assay
T2 - determination of anti-adenovirus antibodies in an infant population.
AU - Weinberg, A.
AU - Fink, M. C.
AU - Takimoto, S.
AU - Ishida, M. A.
AU - Souza, M. C.
PY - 1989
Y1 - 1989
N2 - In order to define an accurate assay for anti-adenovirus antibody detection, a recently developed ELISA was compared with IFA and CF. On 58 sera, the ELISA was more sensitive than both CF and IFA, which showed relative sensitivities of 63% and 94%, respectively. It was not possible to determine the exact specificity of the tests because of the lack of a gold standard. Furthermore, the ELISA was used to define the prevalence of adenovirus antibodies in 116 infants between 1 and 24 months old (mean 7.28). The data showed that maternal antibodies waned by the age of 5 to 6 months and that more than 80% of the children had been infected by adenoviruses by the age of 10 months.
AB - In order to define an accurate assay for anti-adenovirus antibody detection, a recently developed ELISA was compared with IFA and CF. On 58 sera, the ELISA was more sensitive than both CF and IFA, which showed relative sensitivities of 63% and 94%, respectively. It was not possible to determine the exact specificity of the tests because of the lack of a gold standard. Furthermore, the ELISA was used to define the prevalence of adenovirus antibodies in 116 infants between 1 and 24 months old (mean 7.28). The data showed that maternal antibodies waned by the age of 5 to 6 months and that more than 80% of the children had been infected by adenoviruses by the age of 10 months.
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U2 - 10.1590/S0036-46651989000500007
DO - 10.1590/S0036-46651989000500007
M3 - Article
C2 - 2697933
AN - SCOPUS:0024729028
SN - 0036-4665
VL - 31
SP - 336
EP - 340
JO - Revista do Instituto de Medicina Tropical de São Paulo
JF - Revista do Instituto de Medicina Tropical de São Paulo
IS - 5
ER -