TY - JOUR
T1 - Eosinophilic esophagitis
T2 - Interactions with gastroesophageal reflux disease
AU - Cheng, Edaire
AU - Souza, Rhonda F.
AU - Spechler, Stuart Jon
PY - 2014/6
Y1 - 2014/6
N2 - Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are not mutually exclusive. The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. We believe that a clinical or histologic response to PPIs does not rule in GERD or rule out EoE. We recommend a trial of PPI therapy for patients with symptomatic esophageal eosinophilia, even if the diagnosis of EoE seems clear-cut.
AB - Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are not mutually exclusive. The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. We believe that a clinical or histologic response to PPIs does not rule in GERD or rule out EoE. We recommend a trial of PPI therapy for patients with symptomatic esophageal eosinophilia, even if the diagnosis of EoE seems clear-cut.
KW - Eosinophilic esophagitis
KW - Gastroesophageal reflux disease
KW - PPI-responsive esophageal eosinophilia
KW - Proton pump inhibitors
UR - http://www.scopus.com/inward/record.url?scp=84899986243&partnerID=8YFLogxK
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U2 - 10.1016/j.gtc.2014.02.004
DO - 10.1016/j.gtc.2014.02.004
M3 - Review article
C2 - 24813513
AN - SCOPUS:84899986243
SN - 0889-8553
VL - 43
SP - 243
EP - 256
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 2
ER -