TY - JOUR
T1 - Eosinophilic esophagitis
T2 - novel concepts regarding pathogenesis and clinical manifestations
AU - Spechler, Stuart Jon
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/10/1
Y1 - 2019/10/1
N2 - This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing microbial dysbiosis, and (2) that EoE, like eosinophilic gastroenteritis, might have mucosal-predominant and muscle-predominant forms, and that the muscle-predominant form of EoE might cause a variety of esophageal motility disorders including achalasia.
AB - This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing microbial dysbiosis, and (2) that EoE, like eosinophilic gastroenteritis, might have mucosal-predominant and muscle-predominant forms, and that the muscle-predominant form of EoE might cause a variety of esophageal motility disorders including achalasia.
KW - Achalasia
KW - Esophageal motility
KW - Proton pump inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85069715229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069715229&partnerID=8YFLogxK
U2 - 10.1007/s00535-019-01604-7
DO - 10.1007/s00535-019-01604-7
M3 - Review article
C2 - 31342146
AN - SCOPUS:85069715229
SN - 0944-1174
VL - 54
SP - 837
EP - 844
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
IS - 10
ER -