TY - JOUR
T1 - Eosinophilic esophagitis
T2 - When to suspect and why to treat with proton pump inhibitors
AU - Souza, Rhonda F.
N1 - Publisher Copyright:
© 2019, Shugar Publishing Inc. All rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease driven by food allergens that manifests with symptoms of esophageal dysfunction and eosinophil-predominate esophageal inflammation. Since the early 1990s, the frequency of EoE has exploded for unclear reasons. Treatment of EoE with diet therapy or topical steroids, which are potent anti-inflammatory agents, makes sense for management of an allergic condition triggered by food antigens. Recent consensus guidelines now include proton pump inhibitor therapy as an alternative first-line treatment. This review will provide an overview of when to suspect and how to diagnosis EoE, concepts surrounding pathogenesis and increasing incidence of this newly recognized esophageal condition, and a discussion on why proton pump inhibitors are now being used as a first-line treatment strategy.
AB - Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease driven by food allergens that manifests with symptoms of esophageal dysfunction and eosinophil-predominate esophageal inflammation. Since the early 1990s, the frequency of EoE has exploded for unclear reasons. Treatment of EoE with diet therapy or topical steroids, which are potent anti-inflammatory agents, makes sense for management of an allergic condition triggered by food antigens. Recent consensus guidelines now include proton pump inhibitor therapy as an alternative first-line treatment. This review will provide an overview of when to suspect and how to diagnosis EoE, concepts surrounding pathogenesis and increasing incidence of this newly recognized esophageal condition, and a discussion on why proton pump inhibitors are now being used as a first-line treatment strategy.
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M3 - Article
AN - SCOPUS:85073360847
SN - 0277-4208
VL - 43
SP - 21
EP - 28
JO - Practical Gastroenterology
JF - Practical Gastroenterology
IS - 1
ER -