EphB Receptors Coordinate Migration and Proliferation in the Intestinal Stem Cell Niche

Johan Holmberg, Maria Genander, Michael M. Halford, Cecilia Annerén, Mariann Sondell, Michael J. Chumley, Robert E. Silvany, Mark Henkemeyer, Jonas Frisén

Research output: Contribution to journalArticlepeer-review

225 Scopus citations

Abstract

More than 1010 cells are generated every day in the human intestine. Wnt proteins are key regulators of proliferation and are known endogenous mitogens for intestinal progenitor cells. The positioning of cells within the stem cell niche in the intestinal epithelium is controlled by B subclass ephrins through their interaction with EphB receptors. We report that EphB receptors, in addition to directing cell migration, regulate proliferation in the intestine. EphB signaling promotes cell-cycle reentry of progenitor cells and accounts for approximately 50% of the mitogenic activity in the adult mouse small intestine and colon. These data establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche.

Original languageEnglish (US)
Pages (from-to)1151-1163
Number of pages13
JournalCell
Volume125
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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