@article{43b0b984f54a4027b138e7687b149e9a,
title = "EphB Receptors Coordinate Migration and Proliferation in the Intestinal Stem Cell Niche",
abstract = "More than 1010 cells are generated every day in the human intestine. Wnt proteins are key regulators of proliferation and are known endogenous mitogens for intestinal progenitor cells. The positioning of cells within the stem cell niche in the intestinal epithelium is controlled by B subclass ephrins through their interaction with EphB receptors. We report that EphB receptors, in addition to directing cell migration, regulate proliferation in the intestine. EphB signaling promotes cell-cycle reentry of progenitor cells and accounts for approximately 50% of the mitogenic activity in the adult mouse small intestine and colon. These data establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche.",
author = "Johan Holmberg and Maria Genander and Halford, {Michael M.} and Cecilia Anner{\'e}n and Mariann Sondell and Chumley, {Michael J.} and Silvany, {Robert E.} and Mark Henkemeyer and Jonas Fris{\'e}n",
note = "Funding Information: We are grateful to F. Sicheri for advice on the generation of a constitutively active EphB2 receptor and to F. Farnebo for help with injections. The ephrin-B2 expression construct was provided by F. Farnebo and M. Sohl, the anti-ephrin-B1 and anti-musashi-1 antibodies were gifts from H. Okano, anti-phospho-Eph antiserum was a gift from M. Greenberg, and APC min mice were provided by G. Greicius and S. Pettersson. This study was supported by grants from the Swedish Cancer Society, the Swedish Research Council, the Karolinska Institute, the G{\"o}ran Gustafsson Foundation, the Tobias Foundation, the Foundation for Strategic Research, and National Institutes of Health (RO1 MH66332, RO1 DK059164, and RO1 DC006225). ",
year = "2006",
month = jun,
doi = "10.1016/j.cell.2006.04.030",
language = "English (US)",
volume = "125",
pages = "1151--1163",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",
}