Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour

Xiao Na Zhu, Xian Dong Liu, Suya Sun, Hanyi Zhuang, Jing Yu Yang, Mark Henkemeyer, Nan Jie Xu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Innate emotion response to environmental stimuli is a fundamental brain function that is controlled by specific neural circuits. Dysfunction of early emotional circuits may lead to neurodevelopmental disorders such as autism and schizophrenia. However, how the functional circuits are formed to prime initial emotional behaviours remain elusive. We reveal here using gene-targeted mutations an essential role for ephrin-B3 ligand-like activity in the development of innate fear in the neonatal brain. We further demonstrate that ephrin-B3 controls axon targeting and coordinates spinogenesis and neuronal activity within the amygdala. The morphological and behavioural abnormalities in ephrin-B3 mutant mice are rescued by conditional knock-in of wild-type ephrin-B3 during the critical period when axon targeting and fear responses are initiated. Our results thus define a key axonal molecule that participates in the wiring of amygdala circuits and helps bring about fear emotion during the important adolescence period.

Original languageEnglish (US)
Article number11096
JournalNature Communications
Volume7
DOIs
StatePublished - Mar 24 2016

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Ephrin-B3
fear
Instinct
axons
Amygdala
Fear
Axons
emotions
Networks (circuits)
brain
Brain
Emotions
schizophrenia
wiring
abnormalities
Electric wiring
Autistic Disorder
mutations
genes
stimuli

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour. / Zhu, Xiao Na; Liu, Xian Dong; Sun, Suya; Zhuang, Hanyi; Yang, Jing Yu; Henkemeyer, Mark; Xu, Nan Jie.

In: Nature Communications, Vol. 7, 11096, 24.03.2016.

Research output: Contribution to journalArticle

Zhu, Xiao Na ; Liu, Xian Dong ; Sun, Suya ; Zhuang, Hanyi ; Yang, Jing Yu ; Henkemeyer, Mark ; Xu, Nan Jie. / Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour. In: Nature Communications. 2016 ; Vol. 7.
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