Ephrin reverse signaling in axon guidance and synaptogenesis

Nan Jie Xu, Mark Henkemeyer

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Axon-cell and axon-dendrite contact is a highly regulated process necessary for the formation of precise neural circuits and a functional neural network. Eph-ephrin interacting molecules on the membranes of axon nerve terminals and target dendrites act as bidirectional ligands/receptors to transduce signals into both the Eph-expressing and ephrin-expressing cells to regulate cytoskeletal dynamics. In particular, recent evidence indicates that ephrin reverse signal transduction events are important in controlling both axonal and dendritic elaborations of neurons in the developing nervous system. Here we review how ephrin reverse signals are transduced into neurons to control maturation of axonal pre-synaptic and dendritic post-synaptic structures.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume23
Issue number1
DOIs
StatePublished - Feb 2012

Fingerprint

Ephrins
Dendrites
Axons
Neurons
Presynaptic Terminals
Nervous System
Signal Transduction
Ligands
Membranes
Axon Guidance

Keywords

  • Axon
  • Dendrite
  • Ephrin
  • Neuron
  • Reverse signaling
  • Synapse

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Ephrin reverse signaling in axon guidance and synaptogenesis. / Xu, Nan Jie; Henkemeyer, Mark.

In: Seminars in Cell and Developmental Biology, Vol. 23, No. 1, 02.2012, p. 58-64.

Research output: Contribution to journalArticle

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