Ephrins in reverse, park and drive

Chad A. Cowan, Mark Henkemeyer

Research output: Contribution to journalReview article

130 Scopus citations

Abstract

Eph receptors and their membrane-anchored ephrin ligands are thought to orchestrate cell movements by transducing bidirectional tyrosine-kinase-mediated signals into both cells expressing the receptors and cells expressing the ligands. Whether the resulting event is repulsion of an axonal growth cone, directing the orderly segmentation of hindbrain rhombomere cells or controlling angiogenic remodelling, such elaborate and diverse cell movements require intricate changes in the actin cytoskeleton, as well as precise regulation of cellular adhesion. Recent work by several groups has begun to link ephrin reverse signals to intracellular pathways that regulate actin dynamics and might help to explain how these ligands function as receptors to direct cell movement, adhesion and de-adhesion events.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalTrends in Cell Biology
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2002

ASJC Scopus subject areas

  • Cell Biology

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