This article outlines the epidemiology and role of nonsteroidal antiinflammatory drugs (NSAIDs) in causing gastrointestinal (GI) bleeding. The morbidity and mortality associated with NSAID-induced GI bleeding are discussed, and the mechanisms of NSAID-related GI injury, the potency of various NSAIDs, new NSAIDs associated with a decrease in GI pathology, dual-acting antiinflammatory drugs, hydrogen sulfide-releasing NSAIDs, lipoxygenase/cyclooxygenase, phospholipid NSAIDs, and the comprehensive effects of NSAIDs on the GI tract are described.
|Original language||English (US)|
|Number of pages||16|
|Journal||Gastrointestinal Endoscopy Clinics of North America|
|State||Published - Oct 2011|
- Gastrointestinal tract
- Nonsteroidal antiinflammatory drugs
ASJC Scopus subject areas