Epidemiology and Role of Nonsteroidal Antiinflammatory Drugs in Causing Gastrointestinal Bleeding

Iris Lee, Byron Cryer

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

This article outlines the epidemiology and role of nonsteroidal antiinflammatory drugs (NSAIDs) in causing gastrointestinal (GI) bleeding. The morbidity and mortality associated with NSAID-induced GI bleeding are discussed, and the mechanisms of NSAID-related GI injury, the potency of various NSAIDs, new NSAIDs associated with a decrease in GI pathology, dual-acting antiinflammatory drugs, hydrogen sulfide-releasing NSAIDs, lipoxygenase/cyclooxygenase, phospholipid NSAIDs, and the comprehensive effects of NSAIDs on the GI tract are described.

Original languageEnglish (US)
Pages (from-to)597-612
Number of pages16
JournalGastrointestinal Endoscopy Clinics of North America
Volume21
Issue number4
DOIs
StatePublished - Oct 2011

Keywords

  • Epidemiology
  • Gastrointestinal tract
  • Injury
  • Nonsteroidal antiinflammatory drugs
  • Pathogenesis
  • Prevention

ASJC Scopus subject areas

  • Gastroenterology

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