Epidemiology and Role of Nonsteroidal Antiinflammatory Drugs in Causing Gastrointestinal Bleeding

Iris Lee, Byron Cryer

Research output: Contribution to journalReview article

10 Scopus citations


This article outlines the epidemiology and role of nonsteroidal antiinflammatory drugs (NSAIDs) in causing gastrointestinal (GI) bleeding. The morbidity and mortality associated with NSAID-induced GI bleeding are discussed, and the mechanisms of NSAID-related GI injury, the potency of various NSAIDs, new NSAIDs associated with a decrease in GI pathology, dual-acting antiinflammatory drugs, hydrogen sulfide-releasing NSAIDs, lipoxygenase/cyclooxygenase, phospholipid NSAIDs, and the comprehensive effects of NSAIDs on the GI tract are described.

Original languageEnglish (US)
Pages (from-to)597-612
Number of pages16
JournalGastrointestinal Endoscopy Clinics of North America
Issue number4
StatePublished - Oct 1 2011



  • Epidemiology
  • Gastrointestinal tract
  • Injury
  • Nonsteroidal antiinflammatory drugs
  • Pathogenesis
  • Prevention

ASJC Scopus subject areas

  • Gastroenterology

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