Epidemiology of Candida kefyr in patients with hematologic malignancies

Simon F. Dufresne, Kieren A. Marr, Emily Sydnor, Janet F. Staab, Judith E. Karp, Kit Lu, Sean X. Zhang, Christian Lavallée, Trish M. Perl, Dionysios Neofytosa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Candida kefyr is an emerging pathogen among patients with hematologic malignancies (HM). We performed a retrospective study at Johns Hopkins Hospital to evaluate the epidemiology of C. kefyr colonization and infection in HM patients between 2004 and 2010. Eighty-three patients were colonized and/or infected with C. kefyr, with 8 (9.6%) having invasive candidiasis (IC). The yearly incidence of C. kefyr colonization and candidemia increased over the study period (P<0.01), particularly after 2009. In 2010, C. kefyr caused 16.7% of candidemia episodes. The monthly incidence of C. kefyr was higher during the summer throughout the study. In a cohort of patients with acute myelogenic leukemia receiving induction chemotherapy, risks for C. kefyr colonization included the summer season (odds ratio [OR], 3.1; P0.03); administration of an azole (OR, 0.06; P<0.001) or amphotericin B (OR, 0.35; P0.05) was protective. Fingerprinting of 16 isolates by repetitive sequence-based PCR showed that all were different genottypes. The epidemiology of C. kefyr candidemia was evaluated in another hospital in Montreal, Canada; data confirmed higher rates of C. kefyr infection in the summer. C. kefyr appears to be increasing in HM patients, with prominent summer seasonality. These findings raise questions about the effect of antifungal agents and health care exposures (e.g., yogurt) on the epidemiology of this yeast.

Original languageEnglish (US)
Pages (from-to)1830-1837
Number of pages8
JournalJournal of Clinical Microbiology
Volume52
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Hematologic Neoplasms
Candida
Candidemia
Epidemiology
Odds Ratio
Invasive Candidiasis
Azoles
Yogurt
Induction Chemotherapy
Antifungal Agents
Nucleic Acid Repetitive Sequences
Incidence
Amphotericin B
Infection
Canada
Leukemia
Retrospective Studies
Yeasts
Delivery of Health Care
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Dufresne, S. F., Marr, K. A., Sydnor, E., Staab, J. F., Karp, J. E., Lu, K., ... Neofytosa, D. (2014). Epidemiology of Candida kefyr in patients with hematologic malignancies. Journal of Clinical Microbiology, 52(6), 1830-1837. https://doi.org/10.1128/JCM.00131-14

Epidemiology of Candida kefyr in patients with hematologic malignancies. / Dufresne, Simon F.; Marr, Kieren A.; Sydnor, Emily; Staab, Janet F.; Karp, Judith E.; Lu, Kit; Zhang, Sean X.; Lavallée, Christian; Perl, Trish M.; Neofytosa, Dionysios.

In: Journal of Clinical Microbiology, Vol. 52, No. 6, 01.01.2014, p. 1830-1837.

Research output: Contribution to journalArticle

Dufresne, SF, Marr, KA, Sydnor, E, Staab, JF, Karp, JE, Lu, K, Zhang, SX, Lavallée, C, Perl, TM & Neofytosa, D 2014, 'Epidemiology of Candida kefyr in patients with hematologic malignancies', Journal of Clinical Microbiology, vol. 52, no. 6, pp. 1830-1837. https://doi.org/10.1128/JCM.00131-14
Dufresne SF, Marr KA, Sydnor E, Staab JF, Karp JE, Lu K et al. Epidemiology of Candida kefyr in patients with hematologic malignancies. Journal of Clinical Microbiology. 2014 Jan 1;52(6):1830-1837. https://doi.org/10.1128/JCM.00131-14
Dufresne, Simon F. ; Marr, Kieren A. ; Sydnor, Emily ; Staab, Janet F. ; Karp, Judith E. ; Lu, Kit ; Zhang, Sean X. ; Lavallée, Christian ; Perl, Trish M. ; Neofytosa, Dionysios. / Epidemiology of Candida kefyr in patients with hematologic malignancies. In: Journal of Clinical Microbiology. 2014 ; Vol. 52, No. 6. pp. 1830-1837.
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