Epigenetic regulation in medulloblastoma

Jiaqing Yi, Jiang Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Medulloblastoma is the most common malignant childhood brain tumor. The heterogeneous tumors are classified into four subgroups based on transcription profiles. Recent developments in genome-wide sequencing techniques have rapidly advanced the understanding of these tumors. The high percentages of somatic alterations of genes encoding chromatin regulators in all subgroups suggest that epigenetic deregulation is a major driver of medulloblastoma. In this report, we review the current understanding of epigenetic regulation in medulloblastoma with a focus on the functional studies of chromatin regulators in the initiation and progression of specific subgroups of medulloblastoma. We also discuss the potential usage of epigenetic inhibitors for medulloblastoma treatment.

Original languageEnglish (US)
JournalMolecular and Cellular Neuroscience
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Medulloblastoma
Epigenomics
Chromatin
Brain Neoplasms
Neoplasms
Genome
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Epigenetic regulation in medulloblastoma. / Yi, Jiaqing; Wu, Jiang.

In: Molecular and Cellular Neuroscience, 01.01.2017.

Research output: Contribution to journalArticle

@article{93a8b836641a4f7b8a1e03aa471b0da9,
title = "Epigenetic regulation in medulloblastoma",
abstract = "Medulloblastoma is the most common malignant childhood brain tumor. The heterogeneous tumors are classified into four subgroups based on transcription profiles. Recent developments in genome-wide sequencing techniques have rapidly advanced the understanding of these tumors. The high percentages of somatic alterations of genes encoding chromatin regulators in all subgroups suggest that epigenetic deregulation is a major driver of medulloblastoma. In this report, we review the current understanding of epigenetic regulation in medulloblastoma with a focus on the functional studies of chromatin regulators in the initiation and progression of specific subgroups of medulloblastoma. We also discuss the potential usage of epigenetic inhibitors for medulloblastoma treatment.",
author = "Jiaqing Yi and Jiang Wu",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.mcn.2017.09.003",
language = "English (US)",
journal = "Molecular and Cellular Neuroscience",
issn = "1044-7431",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Epigenetic regulation in medulloblastoma

AU - Yi, Jiaqing

AU - Wu, Jiang

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Medulloblastoma is the most common malignant childhood brain tumor. The heterogeneous tumors are classified into four subgroups based on transcription profiles. Recent developments in genome-wide sequencing techniques have rapidly advanced the understanding of these tumors. The high percentages of somatic alterations of genes encoding chromatin regulators in all subgroups suggest that epigenetic deregulation is a major driver of medulloblastoma. In this report, we review the current understanding of epigenetic regulation in medulloblastoma with a focus on the functional studies of chromatin regulators in the initiation and progression of specific subgroups of medulloblastoma. We also discuss the potential usage of epigenetic inhibitors for medulloblastoma treatment.

AB - Medulloblastoma is the most common malignant childhood brain tumor. The heterogeneous tumors are classified into four subgroups based on transcription profiles. Recent developments in genome-wide sequencing techniques have rapidly advanced the understanding of these tumors. The high percentages of somatic alterations of genes encoding chromatin regulators in all subgroups suggest that epigenetic deregulation is a major driver of medulloblastoma. In this report, we review the current understanding of epigenetic regulation in medulloblastoma with a focus on the functional studies of chromatin regulators in the initiation and progression of specific subgroups of medulloblastoma. We also discuss the potential usage of epigenetic inhibitors for medulloblastoma treatment.

UR - http://www.scopus.com/inward/record.url?scp=85038353869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038353869&partnerID=8YFLogxK

U2 - 10.1016/j.mcn.2017.09.003

DO - 10.1016/j.mcn.2017.09.003

M3 - Article

C2 - 29269116

AN - SCOPUS:85038353869

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

SN - 1044-7431

ER -