Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCellular and Molecular Life Sciences
DOIs
StateAccepted/In press - Oct 14 2017

Keywords

  • ATP-dependent chromatin remodeler
  • Chromatin reprogramming
  • Epigenetic eraser
  • Epigenetic reader
  • Epigenetic writer
  • Gene regulation
  • Hypoxia-inducible factor

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Fingerprint Dive into the research topics of 'Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity'. Together they form a unique fingerprint.

  • Cite this