Epigenetic regulators

multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCellular and Molecular Life Sciences
DOIs
StateAccepted/In press - Oct 14 2017

Fingerprint

Protein Stability
Epigenomics
Proteins
Transcriptional Activation
Transcription Factors
Hypoxia
Genes

Keywords

  • ATP-dependent chromatin remodeler
  • Chromatin reprogramming
  • Epigenetic eraser
  • Epigenetic reader
  • Epigenetic writer
  • Gene regulation
  • Hypoxia-inducible factor

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

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title = "Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity",
abstract = "The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.",
keywords = "ATP-dependent chromatin remodeler, Chromatin reprogramming, Epigenetic eraser, Epigenetic reader, Epigenetic writer, Gene regulation, Hypoxia-inducible factor",
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AU - Wang, Yingfei

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AB - The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.

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KW - Epigenetic reader

KW - Epigenetic writer

KW - Gene regulation

KW - Hypoxia-inducible factor

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