Epigenetics and Psychiatry

Melissa Mahgoub, Lisa M Monteggia

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Psychiatric disorders including major depressive disorder, drug addiction, and schizophrenia are debilitating illnesses with a multitude of complex symptoms underlying each of these disorders. In recent years, it has become appreciated that the onset and development of these disorders goes beyond the one gene-one disease approach. Rather, the involvement of many genes is likely linked to these illnesses, and regulating the activation or silencing of gene function may play a crucial role in contributing to their pathophysiology. Epigenetic modifications such as histone acetylation and deacetylation, as well as DNA methylation can induce lasting and stable changes in gene expression, and have therefore been implicated in promoting the adaptive behavioral and neuronal changes that accompany each of these illnesses. In this review we will discuss some of the latest work implicating a potential role for epigenetics in psychiatric disorders, namely, depression, addiction, and schizophrenia as well as a possible role in treatment.

Original languageEnglish (US)
Pages (from-to)734-741
Number of pages8
JournalNeurotherapeutics
Volume10
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Epigenomics
Psychiatry
Schizophrenia
Major Depressive Disorder
Gene Silencing
DNA Methylation
Acetylation
Histones
Genes
Substance-Related Disorders
Depression
Gene Expression

Keywords

  • Addiction
  • Depression
  • Epigenetics
  • Histone
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

Cite this

Epigenetics and Psychiatry. / Mahgoub, Melissa; Monteggia, Lisa M.

In: Neurotherapeutics, Vol. 10, No. 4, 10.2013, p. 734-741.

Research output: Contribution to journalArticle

Mahgoub, Melissa ; Monteggia, Lisa M. / Epigenetics and Psychiatry. In: Neurotherapeutics. 2013 ; Vol. 10, No. 4. pp. 734-741.
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