Epilepsy treatment patterns among patients with tuberous sclerosis complex

Jinlin Song, Elyse Swallow, Qayyim Said, Miranda Peeples, Mark Meiselbach, James Signorovitch, Michael Kohrman, Bruce Korf, Darcy Krueger, Michael Wong, Steven Sparagana

Research output: Contribution to journalArticle

Abstract

Introduction: Tuberous sclerosis complex (TSC) is a rare congenital disorder often associated with epilepsy. However, real-world treatment patterns for epilepsy in patients with TSC are not yet well categorized. Methods: This study included patients with TSC and epilepsy from fifteen clinics in the United States and one in Belgium who were enrolled in the TSC Natural History Database (2006–2014). Patient demographics and epilepsy treatment patterns, including the use of anti-epileptic drugs (AEDs), epilepsy surgeries, and dietary therapies were assessed. Results: Of the 1328 patients with TSC in the database, 1110 (83.6%) were diagnosed with epilepsy. The median age of epilepsy diagnosis was 0.7 years. Of those who received treatment for epilepsy (92.3%), 99.5% were prescribed AEDs, 25.3% underwent surgery, 7.9% were prescribed special diets, and 1% were prescribed mammalian target of rapamycin (mTOR) inhibitors. Of the patients receiving AEDs, over half (64.5%) used ≥3 different AEDs, and 22.5% underwent surgical treatment following AED initiation. Of the patients who underwent surgery, 35.1% had subsequent surgery. Conclusion: The use of multiple AEDs and surgical interventions may indicate a need for new therapies to reduce the treatment burden among patients with TSC and epilepsy.

Original languageEnglish (US)
Pages (from-to)104-108
Number of pages5
JournalJournal of the Neurological Sciences
Volume391
DOIs
StatePublished - Aug 15 2018

Fingerprint

Tuberous Sclerosis
Epilepsy
Pharmaceutical Preparations
Therapeutics
Databases
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Belgium
Sirolimus
Natural History
Demography
Diet

Keywords

  • Anti-epileptic drugs
  • Epilepsy
  • Treatment patterns
  • Tuberous sclerosis complex
  • Tuberous Sclerosis Natural History Database

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Epilepsy treatment patterns among patients with tuberous sclerosis complex. / Song, Jinlin; Swallow, Elyse; Said, Qayyim; Peeples, Miranda; Meiselbach, Mark; Signorovitch, James; Kohrman, Michael; Korf, Bruce; Krueger, Darcy; Wong, Michael; Sparagana, Steven.

In: Journal of the Neurological Sciences, Vol. 391, 15.08.2018, p. 104-108.

Research output: Contribution to journalArticle

Song, J, Swallow, E, Said, Q, Peeples, M, Meiselbach, M, Signorovitch, J, Kohrman, M, Korf, B, Krueger, D, Wong, M & Sparagana, S 2018, 'Epilepsy treatment patterns among patients with tuberous sclerosis complex', Journal of the Neurological Sciences, vol. 391, pp. 104-108. https://doi.org/10.1016/j.jns.2018.06.011
Song J, Swallow E, Said Q, Peeples M, Meiselbach M, Signorovitch J et al. Epilepsy treatment patterns among patients with tuberous sclerosis complex. Journal of the Neurological Sciences. 2018 Aug 15;391:104-108. https://doi.org/10.1016/j.jns.2018.06.011
Song, Jinlin ; Swallow, Elyse ; Said, Qayyim ; Peeples, Miranda ; Meiselbach, Mark ; Signorovitch, James ; Kohrman, Michael ; Korf, Bruce ; Krueger, Darcy ; Wong, Michael ; Sparagana, Steven. / Epilepsy treatment patterns among patients with tuberous sclerosis complex. In: Journal of the Neurological Sciences. 2018 ; Vol. 391. pp. 104-108.
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