Epithelial cells and their neighbors. IV. Bacterial contributions to intestinal epithelial barrier integrity

Anisa S. Ismail, Lora V. Hooper

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Mammalian intestinal surfaces are in constant and intimate contact with a vast consortium of indigenous commensal bacteria. As a result, gut epithelia have evolved an array of strategies for limiting bacterial invasion into deeper tissues, helping to preserve the mutually beneficial nature of intestinal host-microbial relationships. In this review, we discuss a growing body of evidence indicating that commensal bacteria are actively involved in shaping the very barriers that confine them to the gut lumen. By modulating epithelial inflammatory responses, antimicrobial protein expression, and tissue repair functions, indigenous microbial populations are essential for the maintenance of healthy mucosal surfaces.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume289
Issue number5 52-5
DOIs
StatePublished - Nov 2005

Fingerprint

Epithelial Cells
Bacteria
Population Groups
Epithelium
Maintenance
Proteins

Keywords

  • Commensal
  • Epithelium
  • Inflammation
  • Intestinal bacteria
  • Mucosal repair

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

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