Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation

Rachael B. Chanin, Maria G. Winter, Luisella Spiga, Elizabeth R. Hughes, Wenhan Zhu, Savannah J. Taylor, Alexandre Arenales, Caroline C. Gillis, Lisa Büttner, Angel G. Jimenez, Madeline P. Smoot, Renato L. Santos, Sebastian E. Winter

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

During inflammation, the intestinal epithelium produces antimicrobial products to impede bacterial growth. Chanin et al., report that one of these antimicrobial products, reactive oxygen species, also promotes the outgrowth of E. coli. Detoxification of inflammatory reactive oxygen species through AppBCX allows E. coli to respire in an otherwise anaerobic environment.

Original languageEnglish (US)
Pages (from-to)780-788.e5
JournalCell Host and Microbe
Volume28
Issue number6
DOIs
StatePublished - Dec 9 2020

Keywords

  • cytochrome oxidase
  • gut inflammation
  • gut microbiota dysbiosis
  • intestinal epithelium
  • microbial respiration
  • reactive oxygen species

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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