TY - JOUR
T1 - Epithelial ovarian carcinoma in patients with intersex disorders
T2 - The role of pituitary gonadotropins in ovarian tumorigenesis
AU - Miller, David Scott
AU - Teng, Nelson N H
AU - Ballon, Samuel C.
PY - 1986/7
Y1 - 1986/7
N2 - The common epithelial tumors of the human ovary have rarely been found in the gonads of intersex patients with gonadal dysgenesis or true hermaphroditism. This report describes a patient with ovarian serous cystadenocarcinoma and mixed gonadal dysgenesis ( 45,X 46,XY) and reviews other reported cases. Intersex patients require early evaluation with treatment based on the karyotypic risk of malignant gonadal transformation. Epithelial ovarian tumors arising in dysgenetic gonads, which lack ova and are incapable of ovulating, provide a unique model for understanding the role of pituitary gonadotropins in ovarian epithelial tumorigenesis.
AB - The common epithelial tumors of the human ovary have rarely been found in the gonads of intersex patients with gonadal dysgenesis or true hermaphroditism. This report describes a patient with ovarian serous cystadenocarcinoma and mixed gonadal dysgenesis ( 45,X 46,XY) and reviews other reported cases. Intersex patients require early evaluation with treatment based on the karyotypic risk of malignant gonadal transformation. Epithelial ovarian tumors arising in dysgenetic gonads, which lack ova and are incapable of ovulating, provide a unique model for understanding the role of pituitary gonadotropins in ovarian epithelial tumorigenesis.
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U2 - 10.1016/0090-8258(86)90306-9
DO - 10.1016/0090-8258(86)90306-9
M3 - Article
C2 - 2424810
AN - SCOPUS:0022515412
SN - 0090-8258
VL - 24
SP - 299
EP - 308
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -