Epithelial ovarian carcinoma in patients with intersex disorders: The role of pituitary gonadotropins in ovarian tumorigenesis

David Scott Miller, Nelson N H Teng, Samuel C. Ballon

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Abstract

The common epithelial tumors of the human ovary have rarely been found in the gonads of intersex patients with gonadal dysgenesis or true hermaphroditism. This report describes a patient with ovarian serous cystadenocarcinoma and mixed gonadal dysgenesis ( 45,X 46,XY) and reviews other reported cases. Intersex patients require early evaluation with treatment based on the karyotypic risk of malignant gonadal transformation. Epithelial ovarian tumors arising in dysgenetic gonads, which lack ova and are incapable of ovulating, provide a unique model for understanding the role of pituitary gonadotropins in ovarian epithelial tumorigenesis.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalGynecologic Oncology
Volume24
Issue number3
DOIs
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

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