EPITHELIOID ANGIOMATOSIS: A DISTINCT VASCULAR DISORDER IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME OR AIDS-RELATED COMPLEX

ClayJ Cockerell, GuyF Webster, MichaelA Whitlow, AlvinE Friedman-Kien

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Unusual cutaneous vascular neoplasms distinct from Kaposi's sarcoma were observed in five patients with the acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV)-1 infection. The cutaneous lesions were solitary or multiple papules and nodules. In some patients the lesions also affected internal organs. Histologically the neoplasms were composed of proliferating blood vessels and cells with epithelioid features. Immunoperoxidase studies of one lesion showed that the cells expressed both factor VIII antigen, a marker for endothelial cells, and α1-anti-chymotrypsin, a marker for histiocytes. In some patients the lesions gradually disappeared but in two they were the cause of death, in one case from disseminated intravascular coagulation and in the other from laryngeal obstruction by the tumour.

Original languageEnglish (US)
Pages (from-to)654-656
Number of pages3
JournalThe Lancet
Volume330
Issue number8560
DOIs
StatePublished - Sep 19 1987

ASJC Scopus subject areas

  • Medicine(all)

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