TY - JOUR
T1 - EPITHELIOID ANGIOMATOSIS
T2 - A DISTINCT VASCULAR DISORDER IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME OR AIDS-RELATED COMPLEX
AU - Cockerell, ClayJ
AU - Webster, GuyF
AU - Whitlow, MichaelA
AU - Friedman-Kien, AlvinE
N1 - Funding Information:
HIV and HIV antibodies were not done. Other authors have described telangiectases on the chesty hyperalgesic pseudothrombophlebitis,’ facial rubor, rosacea-like telangiectases, and histological features in the early stages of Kaposi’s sarcoma in clinically normal skin in patients with HIV-infection of AID S. We have also seen proliferations of spindle cells around pre-existing vascular plexuses taken from only slightly pinkish macular lesions in patients with AIDS. These may represent the earliest manifestations of Kaposi’s sarcoma (Kuttner B, Ackerman AB, et al, personal communication). Wick and others8 have described multiple pyogenic granulomas in patients with underlying neoplastic diseases, specifically visceral malignancy. Although we do not know why multiple vascular neoplasms arise in patients with AIDS or other diseases, their development may represent a "reactive" process to mast cell products that induce inflammatory-cell infiltration and vascular proliferation.9,lo Alternatively, local or systemic angiogenesis factors may cause proliferation of endothelial cells. Finally there is the possibility that epithelioid haemangiomas and AIDS-associated Kaposi’s sarcoma represent a viral infection, perhaps by an unidentified virus, exerting its effect in the presence of HIV infection and resulting immunodeficiency, or by human immuno- deficiency virus type 2.11 We thank Dr Hosoon Dinscoy at Kings County Hospital, Brooklyn, NY, for permitting us to review the necropsy findings on one case, William Slue for taking the clinical photographs, and William Atkinson for taking the histological photomicrographs. This work was partially supported by the
PY - 1987/9/19
Y1 - 1987/9/19
N2 - Unusual cutaneous vascular neoplasms distinct from Kaposi's sarcoma were observed in five patients with the acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV)-1 infection. The cutaneous lesions were solitary or multiple papules and nodules. In some patients the lesions also affected internal organs. Histologically the neoplasms were composed of proliferating blood vessels and cells with epithelioid features. Immunoperoxidase studies of one lesion showed that the cells expressed both factor VIII antigen, a marker for endothelial cells, and α1-anti-chymotrypsin, a marker for histiocytes. In some patients the lesions gradually disappeared but in two they were the cause of death, in one case from disseminated intravascular coagulation and in the other from laryngeal obstruction by the tumour.
AB - Unusual cutaneous vascular neoplasms distinct from Kaposi's sarcoma were observed in five patients with the acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV)-1 infection. The cutaneous lesions were solitary or multiple papules and nodules. In some patients the lesions also affected internal organs. Histologically the neoplasms were composed of proliferating blood vessels and cells with epithelioid features. Immunoperoxidase studies of one lesion showed that the cells expressed both factor VIII antigen, a marker for endothelial cells, and α1-anti-chymotrypsin, a marker for histiocytes. In some patients the lesions gradually disappeared but in two they were the cause of death, in one case from disseminated intravascular coagulation and in the other from laryngeal obstruction by the tumour.
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U2 - 10.1016/S0140-6736(87)92442-1
DO - 10.1016/S0140-6736(87)92442-1
M3 - Article
C2 - 2887942
AN - SCOPUS:0023186573
SN - 0140-6736
VL - 330
SP - 654
EP - 656
JO - The Lancet
JF - The Lancet
IS - 8560
ER -