Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets

J. R. Falck, S. Manna, J. Moltz, N. Chacos, J. Capdevila

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the invitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

Original languageEnglish (US)
Pages (from-to)743-749
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume114
Issue number2
DOIs
StatePublished - Jul 29 1983

Fingerprint

Glucagon
Islets of Langerhans
Rats
Insulin
Acids
Indomethacin
Cytochrome P-450 Enzyme System
Arginine
Glucose
arachidonate epoxygenase
metapyrone

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. / Falck, J. R.; Manna, S.; Moltz, J.; Chacos, N.; Capdevila, J.

In: Biochemical and Biophysical Research Communications, Vol. 114, No. 2, 29.07.1983, p. 743-749.

Research output: Contribution to journalArticle

@article{b1ca6bcf784149d28e2171f3e9f08a6e,
title = "Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets",
abstract = "Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the invitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.",
author = "Falck, {J. R.} and S. Manna and J. Moltz and N. Chacos and J. Capdevila",
year = "1983",
month = "7",
day = "29",
doi = "10.1016/0006-291X(83)90843-4",
language = "English (US)",
volume = "114",
pages = "743--749",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets

AU - Falck, J. R.

AU - Manna, S.

AU - Moltz, J.

AU - Chacos, N.

AU - Capdevila, J.

PY - 1983/7/29

Y1 - 1983/7/29

N2 - Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the invitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

AB - Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the invitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

UR - http://www.scopus.com/inward/record.url?scp=0020956157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020956157&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(83)90843-4

DO - 10.1016/0006-291X(83)90843-4

M3 - Article

VL - 114

SP - 743

EP - 749

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -