Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets

J. R. Falck, S. Manna, J. Moltz, N. Chacos, J. Capdevila

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the invitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

Original languageEnglish (US)
Pages (from-to)743-749
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume114
Issue number2
DOIs
StatePublished - Jul 29 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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