Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

J R Falck, L. Manmohan Reddy, Kihwan Byun, William B. Campbell, Xiu Yu Yi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

Original languageEnglish (US)
Pages (from-to)2634-2638
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number9
DOIs
StatePublished - May 1 2007

Keywords

  • EETs
  • Eicosanoids
  • Epoxygenase
  • Tetrahydrofuran
  • Vasorelaxation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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