Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity

J R Falck, L. Manmohan Reddy, Kihwan Byun, William B. Campbell, Xiu Yu Yi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from d-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

Original languageEnglish (US)
Pages (from-to)2634-2638
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number9
DOIs
StatePublished - May 1 2007

Fingerprint

Eicosanoids
Metabolites
Arteries
Glucose
Acids
tetrahydrofuran

Keywords

  • EETs
  • Eicosanoids
  • Epoxygenase
  • Tetrahydrofuran
  • Vasorelaxation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Epoxygenase eicosanoids : Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity. / Falck, J R; Manmohan Reddy, L.; Byun, Kihwan; Campbell, William B.; Yi, Xiu Yu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 9, 01.05.2007, p. 2634-2638.

Research output: Contribution to journalArticle

Falck, J R ; Manmohan Reddy, L. ; Byun, Kihwan ; Campbell, William B. ; Yi, Xiu Yu. / Epoxygenase eicosanoids : Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 9. pp. 2634-2638.
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