Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit

R. W. Haley, N. B. Cushion, F. C. Tenover, T. L. Bannerman, D. Dryer, J. Ross, P. J. Sanchez, J. D. Siegel

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Abstract

To control infections with endemic methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit (NICU), triple dye was applied to the umbilical cords of infants in the intermediate-care but not the intensive-care area. The rate of MRSA infection, adjusted for time and intensity of care, decreased in the intermediate-care area (rate ratio, 0.35; 95% confidence interval [CI], 0.14-0.87; P < .01) but not in the intensive- care area (rate ratio, 0.92; 95% CI, 0.41-2.24; P = .48). After 22 months, the rate increased in both areas (Mantel-Haenszel rate ratio, 1.7; 95% CI, 1.0-2.8; P < .05) after overcrowding and understating increased. After temporary reduction of overcrowding and understaffing, extension of triple dye use to the intensive-care area and dedication of an infection control nurse to the NICU, MRSA colonization and infection rates decreased to near zero in both areas (infection rate ratios, 0.09 and 0.11, respectively; P < .005). The endemic MRSA strain, identified by pulsed-field gel electrophoresis, was eradicated.

Original languageEnglish (US)
Pages (from-to)614-624
Number of pages11
JournalJournal of Infectious Diseases
Volume171
Issue number3
StatePublished - 1995

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Neonatal Intensive Care Units
Methicillin-Resistant Staphylococcus aureus
Critical Care
Confidence Intervals
Infection Control
Infection
Umbilical Cord
Pulsed Field Gel Electrophoresis
Anniversaries and Special Events
Nurses
Triple Dye

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Haley, R. W., Cushion, N. B., Tenover, F. C., Bannerman, T. L., Dryer, D., Ross, J., ... Siegel, J. D. (1995). Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit. Journal of Infectious Diseases, 171(3), 614-624.

Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit. / Haley, R. W.; Cushion, N. B.; Tenover, F. C.; Bannerman, T. L.; Dryer, D.; Ross, J.; Sanchez, P. J.; Siegel, J. D.

In: Journal of Infectious Diseases, Vol. 171, No. 3, 1995, p. 614-624.

Research output: Contribution to journalArticle

Haley, RW, Cushion, NB, Tenover, FC, Bannerman, TL, Dryer, D, Ross, J, Sanchez, PJ & Siegel, JD 1995, 'Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit', Journal of Infectious Diseases, vol. 171, no. 3, pp. 614-624.
Haley, R. W. ; Cushion, N. B. ; Tenover, F. C. ; Bannerman, T. L. ; Dryer, D. ; Ross, J. ; Sanchez, P. J. ; Siegel, J. D. / Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 3. pp. 614-624.
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abstract = "To control infections with endemic methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit (NICU), triple dye was applied to the umbilical cords of infants in the intermediate-care but not the intensive-care area. The rate of MRSA infection, adjusted for time and intensity of care, decreased in the intermediate-care area (rate ratio, 0.35; 95{\%} confidence interval [CI], 0.14-0.87; P < .01) but not in the intensive- care area (rate ratio, 0.92; 95{\%} CI, 0.41-2.24; P = .48). After 22 months, the rate increased in both areas (Mantel-Haenszel rate ratio, 1.7; 95{\%} CI, 1.0-2.8; P < .05) after overcrowding and understating increased. After temporary reduction of overcrowding and understaffing, extension of triple dye use to the intensive-care area and dedication of an infection control nurse to the NICU, MRSA colonization and infection rates decreased to near zero in both areas (infection rate ratios, 0.09 and 0.11, respectively; P < .005). The endemic MRSA strain, identified by pulsed-field gel electrophoresis, was eradicated.",
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