Mitogen-activated protein kinase (MAPK) cascades are tightly controlled through a series of well-characterized phospho-regulatory events. In this issue, Takeda et al () identify the inhibitor of apoptosis protein, XIAP, as a key regulator of ERK5 activation via uncoupling of upstream kinase activity by non-degradative ubiquitination. The inhibitor of apoptosis (IAP) family proteins is identified as suppressors of MAPK signaling. Mechanistically, IAPs function as upstream kinase uncoupler by virtue of non-degradative ubiquitination.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)