Erlotinib hydrochloride

Jonathan Dowell; John D. Minna; Peter Kirkpatrick

doi:10.1038/nrd1730

Erlotinib hydrochloride

Jonathan Dowell, John D. Minna, Peter Kirkpatrick

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Abstract

Erlotinib hydrochloride (Tarceva; OSI Pharmaceuticals/Genentech/Roche), a member of a class of targeted anticancer drugs that inhibit the activity of the epidermal growth factor receptor, was approved by the US FDA in November 2004 for the treatment of advanced non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. It is the first such drug to demonstrate an increase in survival in Phase III trials in patients with advanced non-small-cell lung cancer.

Original language	English (US)
Pages (from-to)	S14-S15
Journal	Nature Reviews Drug Discovery
Volume	4
Issue number	5 SUPPL.
DOIs	https://doi.org/10.1038/nrd1730
State	Published - May 2005

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/nrd1730

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title = "Erlotinib hydrochloride",

abstract = "Erlotinib hydrochloride (Tarceva; OSI Pharmaceuticals/Genentech/Roche), a member of a class of targeted anticancer drugs that inhibit the activity of the epidermal growth factor receptor, was approved by the US FDA in November 2004 for the treatment of advanced non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. It is the first such drug to demonstrate an increase in survival in Phase III trials in patients with advanced non-small-cell lung cancer.",

author = "Jonathan Dowell and Minna, {John D.} and Peter Kirkpatrick",

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AU - Kirkpatrick, Peter

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AB - Erlotinib hydrochloride (Tarceva; OSI Pharmaceuticals/Genentech/Roche), a member of a class of targeted anticancer drugs that inhibit the activity of the epidermal growth factor receptor, was approved by the US FDA in November 2004 for the treatment of advanced non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. It is the first such drug to demonstrate an increase in survival in Phase III trials in patients with advanced non-small-cell lung cancer.

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Erlotinib hydrochloride

Abstract

ASJC Scopus subject areas

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