Erratum to: Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice: LYMPHATIC ENDOTHELIAL CELLS CAUSE BONE LOSS VIA M-CSF (Journal of Bone and Mineral Research, (2017), 32, 5, (939-950), 10.1002/jbmr.3077)

A reader of the JBMR informed the editors about concern regarding Fig. in Wang and colleagues. In consultation with the Committee on Publication Ethics (COPE) guidelines, the editors sought an explanation from the authors for this error. 6 (Figure presented.) Lymphatic endothelial cells in bone samples from a GSD patient express M-CSF. Paraffin sections of a bone sample from a female GSD patient were stained with H&E and then processed for immunofluorescence staining with anti-LYVE-1 and M-CSF antibodies. Sections were scanned using an Olympus VS120 whole-slide imaging system. (A) H&E section showing the areas used for fluorescence imaging (color boxes). An M-CSF+/LYVE-1+ lymphatic vessel is indicated by “*” in the yellow box and an M-CSF–/LYVE-1+ lymphatic vessel is indicated by “#” in the green box. (B) Enlarged fluorescence images from the regions in A showing an M-CSF+/LYVE-1+ lymphatic vessel and a portion of M-CSF–/LYVE-1+ lymphatic vessel (left panels) and an M-CSF–/LYVE-1+ lymphatic vessel (right panels). B = bone. [Color figure can be viewed at wileyonlinelibrary.com] The reader noted that the two separate panels in Fig. A appeared to have been taken from the same section and shown at different magnifications. Indeed, the two images were deliberately taken from the same bone tissue section from a patient with Gorham-Stout disease (GSD). The authors acknowledge that the figure legend and Materials and Method section were not sufficiently clear, and have revised the figure and legend. The revised figure below now shows the H&E section as a single image (Fig. A), and the color-coded rectangles indicate the two regions that were used for the immunofluorescence images of Fig. B. Figure A shows an M-CSF+/LYVE-1+ lymphatic vessel (indicated by the yellow box) and an M-CSF–/LYVE-1+ lymphatic vessel (indicated by the green box). The authors have also included scale bars, which were missing from the original images. The authors regret any confusion and inconvenience this may have caused the readers of the JBMR.