Error-prone DNA polymerases: Novel structures and the benefits of infidelity

Errol C. Friedberg, Paula L. Fischhaber, Caroline Kisker

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalCell
Volume107
Issue number1
DOIs
StatePublished - Oct 5 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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