Error-prone DNA polymerases: Novel structures and the benefits of infidelity

Errol C. Friedberg, Paula L. Fischhaber, Caroline Kisker

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalCell
Volume107
Issue number1
DOIs
StatePublished - Oct 5 2001

Fingerprint

DNA-Directed DNA Polymerase
DNA Damage
DNA
Enzymes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Error-prone DNA polymerases : Novel structures and the benefits of infidelity. / Friedberg, Errol C.; Fischhaber, Paula L.; Kisker, Caroline.

In: Cell, Vol. 107, No. 1, 05.10.2001, p. 9-12.

Research output: Contribution to journalArticle

Friedberg, Errol C. ; Fischhaber, Paula L. ; Kisker, Caroline. / Error-prone DNA polymerases : Novel structures and the benefits of infidelity. In: Cell. 2001 ; Vol. 107, No. 1. pp. 9-12.
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